CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029070
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 BCL-6 corepressor 
Protein Synonyms/Alias
  
Gene Name
 BCOR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
168PAKQQKIKENQKTDVubiquitination[1]
172QKIKENQKTDVLCADubiquitination[2]
303ARRLIVNKNAGETLLubiquitination[1, 2, 3, 4, 5, 6, 7, 8, 9]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [7] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [8] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [9] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 622 AA 
Protein Sequence
MPHSPTLRVD RKRKVSGDSS HTETTAEEVP EDPLLKAKRR RVSKGLHPKK QRHLLHLRER 60
WEQQVSAADG KPGRQSRKEV TQATQPEAIP QGTNITEEKP GRKRAEAKGN RSWSEESLKP 120
SDNEQGLPVF SGSPPMKSLS STSAGGKKQA QPSCAPASRP PAKQQKIKEN QKTDVLCADE 180
EEDCQAASLL QKYTDNSEKP SGKRLCKTKH LIPQESRRGL PLTGEYYVEN ADGKVTVRRF 240
RKRPEPSSDY DLSPAKQEPK PFDRLQQLLP ASQSTQLPCS SSPQETTQSR PMPPEARRLI 300
VNKNAGETLL QRAARLGYEE VVLYCLENKI CDVNHRDNAG YCALHEACAR GWLNIVRHLL 360
EYGADVNCSA QDGTRPLHDA VENDHLEIVR LLLSYGADPT LATYSGRTIM KMTHSELMEK 420
FLTDYLNDLQ GRNDDDASGT WDFYGSSVCE PDDESGYDVL ANPPGPEDQD DDDDAYSDVF 480
EFEFSETPLL PCYNIQVSVA QGPRNWLLLS DVLKKLKMSS RIFRCNFPNV EIVTIAEAEF 540
YRQVSASLLF SCSKDLEAFN PESKELLDLV EFTNEIQTLL GSSVEWLHPS DLASDNYWKS 600
PQIARGSVEG KKTDDKTSKT DL 622 
Gene Ontology
  
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 
Pfam
 PF12796; Ank_2 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS