CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004205
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 L-selectin 
Protein Synonyms/Alias
 CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD62L 
Gene Name
 SELL 
Gene Synonyms/Alias
 LNHR; LYAM1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
91AEIEYLEKTLPFSRSubiquitination[1]
106YYWIGIRKIGGIWTWubiquitination[1]
118WTWVGTNKSLTEEAEubiquitination[1]
136DGEPNNKKNKEDCVEubiquitination[1]
138EPNNKKNKEDCVEIYubiquitination[1]
147DCVEIYIKRNKDAGKubiquitination[1]
150EIYIKRNKDAGKWNDubiquitination[1]
154KRNKDAGKWNDDACHubiquitination[1]
162WNDDACHKLKAALCYubiquitination[1]
312GTELIGKKKTICESSubiquitination[1]
313TELIGKKKTICESSGubiquitination[1]
334PICQKLDKSFSMIKEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. 
Sequence Annotation
 DOMAIN 55 155 C-type lectin.
 DOMAIN 156 192 EGF-like.
 DOMAIN 195 256 Sushi 1.
 DOMAIN 257 318 Sushi 2.
 CARBOHYD 60 60 N-linked (GlcNAc...).
 CARBOHYD 104 104 N-linked (GlcNAc...).
 CARBOHYD 177 177 N-linked (GlcNAc...) (Potential).
 CARBOHYD 232 232 N-linked (GlcNAc...) (Potential).
 CARBOHYD 246 246 N-linked (GlcNAc...) (Potential).
 CARBOHYD 271 271 N-linked (GlcNAc...) (Potential).
 CARBOHYD 311 311 N-linked (GlcNAc...) (Potential).
 DISULFID 57 155 By similarity.
 DISULFID 128 147 By similarity.
 DISULFID 160 171 By similarity.
 DISULFID 165 180 By similarity.
 DISULFID 182 191 By similarity.
 DISULFID 197 241 By similarity.
 DISULFID 227 254 By similarity.
 DISULFID 259 303 By similarity.
 DISULFID 289 316 By similarity.  
Keyword
 3D-structure; Alternative splicing; Cell adhesion; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Lectin; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Sushi; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 372 AA 
Protein Sequence
MGCRRTREGP SKAMIFPWKC QSTQRDLWNI FKLWGWTMLC CDFLAHHGTD CWTYHYSEKP 60
MNWQRARRFC RDNYTDLVAI QNKAEIEYLE KTLPFSRSYY WIGIRKIGGI WTWVGTNKSL 120
TEEAENWGDG EPNNKKNKED CVEIYIKRNK DAGKWNDDAC HKLKAALCYT ASCQPWSCSG 180
HGECVEIINN YTCNCDVGYY GPQCQFVIQC EPLEAPELGT MDCTHPLGNF SFSSQCAFSC 240
SEGTNLTGIE ETTCGPFGNW SSPEPTCQVI QCEPLSAPDL GIMNCSHPLA SFSFTSACTF 300
ICSEGTELIG KKKTICESSG IWSNPSPICQ KLDKSFSMIK EGDYNPLFIP VAVMVTAFSG 360
LAFIIWLARR LKKGKKSKRS MNDPY 385 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0030246; F:carbohydrate binding; TAS:ProtInc.
 GO:0043208; F:glycosphingolipid binding; TAS:BHF-UCL.
 GO:0008201; F:heparin binding; TAS:BHF-UCL.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0050776; P:regulation of immune response; TAS:Reactome.
 GO:0033198; P:response to ATP; IEA:Compara. 
Interpro
 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR018378; C-type_lectin_CS.
 IPR016187; C-type_lectin_fold.
 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR016348; L-selectin.
 IPR002396; Selectin_superfamily.
 IPR000436; Sushi_SCR_CCP. 
Pfam
 PF00008; EGF
 PF00059; Lectin_C
 PF00084; Sushi 
SMART
 SM00032; CCP
 SM00034; CLECT
 SM00181; EGF 
PROSITE
 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS50923; SUSHI 
PRINTS
 PR00343; SELECTIN.