UniProt Accession

 FENR_ECOLI; P28861; P11007; Q2M8M0 

Genbank Protein ID

 L04757; L19201; U00096; AP009048; Z11767; M19644 

Genbank Nucleotide ID

 AAA23805.1; AAB03056.1; AAC76906.1; BAE77386.1; AAA24189.1 

Protein Name

 Ferredoxin--NADP reductase 

Protein Synonyms/Alias

 FNR; DA1; Flavodoxin reductase; FLDR; FLXR; Methyl viologen resistance protein A 

Gene Name

 fpr 

Gene Synonyms/Alias

 mvrA; b3924; JW3895 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
74	LVTVPDGKLSPRLAA	acetylation	[1]
135	GKDLDRFKNLVLVHA	acetylation	[1]
135	GKDLDRFKNLVLVHA	pupylation	[2]
160	PLMQELEKRYEGKLR	acetylation	[1]
226	RDTQQLLKETRQMTK	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli.
 Cerda-Maira FA, McAllister F, Bode NJ, Burns KE, Gygi SP, Darwin KH.
 EMBO Rep. 2011 Jul 8;12(8):863-70. [PMID: 21738222] 

Functional Description

 Transports electrons between flavodoxin or ferredoxin and NADPH. Involved in the reductive activation of cobalamin- independent methionine synthase, pyruvate formate lyase and anaerobic ribonucleotide reductase. Also protects against superoxide radicals due to methyl viologen in the presence of oxygen. 

Sequence Annotation

 DOMAIN 2 101 FAD-binding FR-type.
 NP_BIND 50 53 FAD.
 NP_BIND 74 76 FAD.
 NP_BIND 143 144 NADP (By similarity).
 NP_BIND 173 174 NADP (By similarity).
 NP_BIND 213 214 NADP (By similarity).
 NP_BIND 247 248 FAD.
 BINDING 53 53 NADP (By similarity).
 BINDING 66 66 FAD; via carbonyl oxygen.
 BINDING 116 116 FAD.
 BINDING 116 116 NADP; via amide nitrogen (By similarity).
 BINDING 245 245 NADP (By similarity).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:EcoliWiki.
 GO:0004324; F:ferredoxin-NADP+ reductase activity; IDA:EcoCyc.
 GO:0006001; P:fructose catabolic process; IMP:EcoliWiki.
 GO:0042493; P:response to drug; IMP:EcoliWiki. 

Interpro

 IPR017927; Fd_Rdtase_FAD-bd.
 IPR008333; OxRdtase_FAD-bd_dom.
 IPR001433; OxRdtase_FAD/NAD-bd.
 IPR017938; Riboflavin_synthase-like_b-brl. 

Pfam

 PF00970; FAD_binding_6
 PF00175; NAD_binding_1 

SMART

  

PROSITE

 PS51384; FAD_FR 

PRINTS