CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023711
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WW domain-binding protein 11 
Protein Synonyms/Alias
 WBP-11; Npw38-binding protein; NpwBP; SH3 domain-binding protein SNP70; Splicing factor that interacts with PQBP-1 and PP1 
Gene Name
 WBP11 
Gene Synonyms/Alias
 NPWBP; SIPP1; SNP70 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
13TSSTKSGKFMNPTDQacetylation[1]
105KENPDIYKELRKLEVubiquitination[2, 3, 4]
565ATATISAKPQITNPKacetylation[5]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. 
Sequence Annotation
 REGION 1 45 Required for nuclear import (By
 REGION 217 221 Interaction with PP1 (By similarity).
 REGION 306 310 Interaction with PP1 (By similarity).
 MOTIF 455 466 PGR.
 MOD_RES 13 13 N6-acetyllysine.
 MOD_RES 181 181 Phosphoserine.
 MOD_RES 237 237 Phosphoserine.
 MOD_RES 279 279 Phosphoserine.
 MOD_RES 283 283 Phosphoserine.
 MOD_RES 353 353 Phosphoserine.
 MOD_RES 361 361 Phosphoserine.
 MOD_RES 364 364 Phosphoserine.  
Keyword
 Acetylation; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 641 AA 
Protein Sequence
MGRRSTSSTK SGKFMNPTDQ ARKEARKREL KKNKKQRMMV RAAVLKMKDP KQIIRDMEKL 60
DEMEFNPVQQ PQLNEKVLKD KRKKLRETFE RILRLYEKEN PDIYKELRKL EVEYEQKRAQ 120
LSQYFDAVKN AQHVEVESIP LPDMPHAPSN ILIQDIPLPG AQPPSILKKT SAYGPPTRAV 180
SILPLLGHGV PRLPPGRKPP GPPPGPPPPQ VVQMYGRKVG FALDLPPRRR DEDMLYSPEL 240
AQRGHDDDVS STSEDDGYPE DMDQDKHDDS TDDSDTDKSD GESDGDEFVH RDNGERDNNE 300
EKKSGLSVRF ADMPGKSRKK KKNMKELTPL QAMMLRMAGQ EIPEEGREVE EFSEDDDEDD 360
SDDSEAEKQS QKQHKEESHS DGTSTASSQQ QAPPQSVPPS QIQAPPMPGP PPLGPPPAPP 420
LRPPGPPTGL PPGPPPGAPP FLRPPGMPGL RGPLPRLLPP GPPPGRPPGP PPGPPPGLPP 480
GPPPRGPPPR LPPPAPPGIP PPRPGMMRPP LVPPLGPAPP GLFPPAPLPN PGVLSAPPNL 540
IQRPKADDTS AATIEKKATA TISAKPQITN PKAEITRFVP TALRVRRENK GATAAPQRKS 600
EDDSAVPLAK AAPKSGPSVP VSVQTKDDVY EAFMKEMEGL L 641 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016607; C:nuclear speck; IEA:Compara.
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0008599; F:protein phosphatase type 1 regulator activity; IEA:Compara.
 GO:0003697; F:single-stranded DNA binding; TAS:ProtInc.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR019007; WW_dom-bd_prot_11. 
Pfam
 PF09429; Wbp11 
SMART
  
PROSITE
  
PRINTS