UniProt Accession

 D3YVK1_MOUSE; D3YVK1 

Genbank Protein ID

 AC099702 

Genbank Nucleotide ID

  

Protein Name

 Glutamine synthetase 

Protein Synonyms/Alias

  

Gene Name

 Glul 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
11	SASSHLNKGIKQMYM	ubiquitination	[1]
14	SHLNKGIKQMYMSLP	acetylation	[2]
14	SHLNKGIKQMYMSLP	ubiquitination	[1]
91	MFRDPFRKDPNKLVL	ubiquitination	[1]
95	PFRKDPNKLVLCEVF	ubiquitination	[1]
103	LVLCEVFKYNRKPAE	ubiquitination	[1]
107	EVFKYNRKPAETNLR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 199 AA 

Protein Sequence

Gene Ontology

 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0043204; C:perikaryon; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005791; C:rough endoplasmic reticulum; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0016595; F:glutamate binding; IEA:Compara.
 GO:0004356; F:glutamate-ammonia ligase activity; IEA:Compara.
 GO:0000287; F:magnesium ion binding; IEA:Compara.
 GO:0030145; F:manganese ion binding; IEA:Compara.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0006536; P:glutamate metabolic process; IEA:Compara.
 GO:0006542; P:glutamine biosynthetic process; IEA:Compara.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Compara.
 GO:0032024; P:positive regulation of insulin secretion; IEA:Compara.
 GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IMP:MGI. 

Interpro

 IPR008147; Gln_synt_beta.
 IPR014746; Gln_synth/guanido_kin_cat_dom.
 IPR008146; Gln_synth_cat_dom.
 IPR027302; Gln_synth_N_conserv_site. 

Pfam

 PF00120; Gln-synt_C
 PF03951; Gln-synt_N 

SMART

  

PROSITE

 PS00180; GLNA_1 

PRINTS