UniProt Accession

 MLF1_HUMAN; P58340; E9PEU9; Q2TLE3; Q2TLE5; Q8N8F8; Q96MH1 

Genbank Protein ID

 L49054; AY848700; AY848702; AK056948; AK096889; AK297488; AC025033; AC106707; CH471052; CH471052; BC007045 

Genbank Nucleotide ID

 AAA99997.1; AAX46015.1; AAX46017.1; BAB71320.1; BAC04885.1; BAG59906.1; EAW78689.1; EAW78690.1; AAH07045.1 

Protein Name

 Myeloid leukemia factor 1 

Protein Synonyms/Alias

 Myelodysplasia-myeloid leukemia factor 1 

Gene Name

 MLF1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
122	KIGDEPPKVFQASTQ	ubiquitination	[1]
174	IKKSKNKKTGDEEVN	ubiquitination	[1]
236	RELKRREKPQQSPAI	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. 

Sequence Annotation

 REGION 50 125 Interaction with COPS3.
 MOD_RES 34 34 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Cell cycle; Chromosomal rearrangement; Complete proteome; Cytoplasm; Developmental protein; Differentiation; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 268 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0019904; F:protein domain specific binding; IDA:UniProtKB.
 GO:0007050; P:cell cycle arrest; IDA:UniProtKB.
 GO:0002318; P:myeloid progenitor cell differentiation; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; ISS:UniProtKB. 

Interpro

 IPR019376; Myeloid_leukemia_factor. 

Pfam

 PF10248; Mlf1IP 

SMART

  

PROSITE

  

PRINTS