| Tag | Content |
|---|
| CPLM ID | CPLM-018817 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Signal transducing adapter molecule 1 |
Protein Synonyms/Alias | STAM-1 |
Gene Name | STAM |
Gene Synonyms/Alias | STAM1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 133 | SLISAMIKNLKEQGV | ubiquitination | [1] | | 136 | SAMIKNLKEQGVTFP | ubiquitination | [1] | | 154 | SQAAEQAKASPALVA | ubiquitination | [1] | | 162 | ASPALVAKDPGTVAN | ubiquitination | [1] | | 170 | DPGTVANKKEEEDLA | ubiquitination | [1] | | 171 | PGTVANKKEEEDLAK | ubiquitination | [1] | | 185 | KAIELSLKEQRQQST | ubiquitination | [1] | | 279 | PEMIKTEKKTVQFSD | ubiquitination | [1] | | 353 | KLEDIDRKHSELSEL | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. |
Sequence Annotation | DOMAIN 16 143 VHS.
REPEAT 171 190 UIM.
DOMAIN 210 269 SH3.
DOMAIN 370 387 ITAM.
MOD_RES 156 156 Phosphoserine.
MOD_RES 198 198 Phosphotyrosine.
MOD_RES 381 381 Phosphotyrosine.
MOD_RES 384 384 Phosphotyrosine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; SH3 domain; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 540 AA |
Protein Sequence | MPLFATNPFD QDVEKATSEM NTAEDWGLIL DICDKVGQSR TGPKDCLRSI MRRVNHKDPH 60
VAMQALTLLG ACVSNCGKIF HLEVCSRDFA SEVSNVLNKG HPKVCEKLKA LMVEWTDEFK 120
NDPQLSLISA MIKNLKEQGV TFPAIGSQAA EQAKASPALV AKDPGTVANK KEEEDLAKAI 180
ELSLKEQRQQ STTLSTLYPS TSSLLTNHQH EGRKVRAIYD FEAAEDNELT FKAGEIITVL 240
DDSDPNWWKG ETHQGIGLFP SNFVTADLTA EPEMIKTEKK TVQFSDDVQV ETIEPEPEPA 300
FIDEDKMDQL LQMLQSTDPS DDQPDLPELL HLEAMCHQMG PLIDEKLEDI DRKHSELSEL 360
NVKVMEALSL YTKLMNEDPM YSMYAKLQNQ PGSGPTIRKP SPS 403 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc. GO:0016044; P:cellular membrane organization; TAS:Reactome. GO:0016197; P:endosomal transport; TAS:Reactome. GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome. GO:0006886; P:intracellular protein transport; IEA:InterPro. GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |