CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015802
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin-like protein KIF27 
Protein Synonyms/Alias
  
Gene Name
 Kif27 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
819MRVQVLQKKQQDSKKubiquitination[1]
1084QSRQNSLKASFQNLSubiquitination[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] A proteomics approach to identify the ubiquitinated proteins in mouse heart.
 Jeon HB, Choi ES, Yoon JH, Hwang JH, Chang JW, Lee EK, Choi HW, Park ZY, Yoo YJ.
 Biochem Biophys Res Commun. 2007 Jun 8;357(3):731-6. [PMID: 17451654] 
Functional Description
 Plays an essential role in motile ciliogenesis. 
Sequence Annotation
 DOMAIN 1 269 Kinesin-motor.
 NP_BIND 84 91 ATP (Potential).
 CROSSLNK 1084 1084 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; ATP-binding; Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Isopeptide bond; Microtubule; Motor protein; Nucleotide-binding; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1394 AA 
Protein Sequence
MEEIPIKVAV RIRPLLCKEV LHNHQVCVRD IPNTQQIIIG RDRVFTFDFV FGKNSTQDEV 60
YNTCIKPLVL SLIEGYNATV FAYGQTGSGK TYTIGGGHVA SVVEGQKGII PRAIQEIFQS 120
ISENPSIDFK IKVSYIEVYK EDLRDLLELE TSMKDLHIRE DEKGNTVIVG AKECQVESVE 180
DVMSLLQVGN AARHTGTTQM NEHSSRSHAI FTISVCQVEK NAEAAENGEW YSHRHIVSKF 240
HFVDLAGSER VTKTGNTGER FKESIQINSG LLALGNVISA LGDPRRKSSH IPYRDAKITR 300
LLKDSLGGSA KTVMITCVSP SSSDFDESLN SLKYANRARN IRNKPALNIS PQADRMDEME 360
FEIKLLREAL QSHQASISQA SQASSENVPD QNRIHSLEEQ VAQLQEECLG YQDCIEQAFA 420
FLVDLKDAVK LNQKQQHKLQ EWFSRTQEVR KAVLTPLPGN QGIGNLEEGP QHLTVLQLKR 480
ELKKYQCALA ADQVVFTQKD LELEELRTQV QLMMQESKGH AVSLKEAQKV NRLQNEKIIE 540
QQLLVDQLSA ELAKRSLSVP TSAKESCGDG PDARASEKRP HTAPFESHWG HYVYIPSRQD 600
FKKVCSSTPV YSLDQVFAGF RTRSQMLMGH LEDQDEVLHC QFSDNSDDED SEGQEKPRVR 660
SRSHSWAKKP GSVCSLVELS DTQAESQRSY LGNGDLKMES LQESQEINLQ KLRTSELILN 720
KAKQKMRELT INIRMKEDLI KELIKTGNNA KSVSRQYSLK VTKLEHEAEQ AKVELTETRK 780
QLQELESKDL SDVALKVKLQ KEFRKKMDAA KMRVQVLQKK QQDSKKLASL SIQNEKRASE 840
LEHNVDHLKY QKVQLQRRLR EEGEKKKQLD AEIKRDQQKI KELQLKAGQG EGLNPKAEDQ 900
DGFNLNRRKS PFRSGDQFQK LDEQRKWLDE EVEKVLSQRQ ELEMLEEDLK KREAIVSKKE 960
ALLQEKSLLE NKKLRSSQAL STDGLKISAR LNLLDQELSE KSLQLESSPT EEKMKISEQV 1020
QALQRERDQL QRQRNSVDER LKHGRVLSPK EEHLLFQLEE GIEALEAAIE FKNESIQSRQ 1080
NSLKASFQNL SQSEANVLEK LVCLNITEIR AILFKYFNKV INLRETERKQ QLQNKEMKMK 1140
VLERDNVVHE LESALEHLRL QCDRRLTLQQ KEHEQKMQLL LQHFKDQDGD SIIETLKNYE 1200
DKIQQLEKDL YFYKKTSRDL KKRLKDPAQG AAQWQRTLTE HHDAGDGVLN PEETTVLSEE 1260
LKWASRTENT KLNGSEREVD NSSSSLKTQP LTQQIPEDGP DSLPARSSIA PSSGQLQSIA 1320
DKTEARPFTH SQSPVPHQFQ PVRSIGPLQG VKPVKLCRRE LRQISAMELS LRRCSLGAGG 1380
RSMTADSLED PEEN 1394 
Gene Ontology
 GO:0005929; C:cilium; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0042384; P:cilium assembly; IDA:UniProtKB.
 GO:0003351; P:epithelial cilium movement; IMP:MGI.
 GO:0021591; P:ventricular system development; IMP:MGI. 
Interpro
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00225; Kinesin 
SMART
 SM00129; KISc 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.