| Tag | Content |
|---|
| CPLM ID | CPLM-014291 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nuclear receptor coactivator 2 |
Protein Synonyms/Alias | NCoA-2; Glucocorticoid receptor-interacting protein 1; GRIP-1; Transcriptional intermediary factor 2 |
Gene Name | Ncoa2 |
Gene Synonyms/Alias | Grip1; Tif2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 279 | TRQDLQGKITSLDTS | ubiquitination | [1] | | 640 | HDSKGQTKLLQLLTT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. |
Sequence Annotation | DOMAIN 26 83 bHLH.
DOMAIN 119 183 PAS.
REGION 691 743 CASP8AP2-binding.
MOTIF 641 645 LXXLL motif 1.
MOTIF 690 694 LXXLL motif 2.
MOTIF 745 749 LXXLL motif 3.
MOTIF 878 882 LXXLL motif 4.
MOTIF 1079 1087 LLXXLXXXL motif.
MOD_RES 2 2 N-acetylserine (By similarity).
MOD_RES 487 487 Phosphoserine (By similarity).
MOD_RES 493 493 Phosphoserine.
MOD_RES 499 499 Phosphoserine (By similarity).
MOD_RES 640 640 N6-acetyllysine (By similarity).
MOD_RES 699 699 Phosphoserine.
MOD_RES 716 716 Phosphoserine.
MOD_RES 780 780 N6-acetyllysine (By similarity).
MOD_RES 785 785 N6-acetyllysine (By similarity).
MOD_RES 851 851 Phosphoserine (By similarity). |
Keyword | 3D-structure; Acetylation; Activator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1462 AA |
Protein Sequence | MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA ELIFANFNDI 60
DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS DVSSTGQGVI DKDALGPMML 120
EALDGFFFVV NLEGSVVFVS ENVTQYLRYN QEELMNKSVY SILHVGDHTE FVKNLLPKSM 180
VNGGSWSGEP PRRSSHTFNC RMLVKPLPDS EEEGHDSQEA HQKYEAMQCF AVSQPKSIKE 240
EGEDLQSCLI CVARRVPMKE RPTLPSSESF TTRQDLQGKI TSLDTSTMRA AMKPGWEDLV 300
RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ TKSKLIRSQT 360
TNEPQLVISL HMLHREQNVC VMNPDLTGQA MGKPLNPISS SSPAHQALCS GNPGQDMTLG 420
SNINFPMNGP KEQMGMPMGR FGGSGGMNHV SGMQATTPQG SNYALKMNSP SQSSPGMNPG 480
QASSVLSPRQ RMSPGVAGSP RIPPSQFSPA GSLHSPVGVC SSTGNSHSYT NSSLNALQAL 540
SEGHGVSLGS SLASPDLKMG NLQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA 600
EASCHPEEQK GPNDSSMPQA ASGDRAEGHS RLHDSKGQTK LLQLLTTKSD QMEPSPLPSS 660
LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP VDLAKLTAEA TGKELSQESS 720
STAPGSEVTV KQEPASPKKK ENALLRYLLD KDDTKDIGLP EITPKLERLD SKTDPASNTK 780
LIAMKTVKEE VSFEPSDQPG SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII 840
NDLMQLTADS SPVPPAGAQK AALRMSQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG 900
PFPPIRNSSP YSVIPQPGMM GNQGMLGSQG NLGNNSTGMI GSSTSRPSMP SGEWAPQSPA 960
VRVTCAATTG AMNRPVQGGM IRNPTASIPM RANSQPGQRQ MLQSQVMNIG PSELEMNMGG 1020
PQYNQQQAPP NQTAPWPESI LPIDQASFAS QNRQPFGSSP DDLLCPHPAA ESPSDEGALL 1080
DQLYLALRNF DGLEEIDRAL GIPELVSQSQ AVDAEQFSSQ ESSIMLEQKP PVFPQQYASQ 1140
AQMAQGGYNP MQDPNFHTMG QRPNYTTLRM QPRPGLRPTG IVQNQPNQLR LQLQHRLQAQ 1200
QNRQPLMNQI SSVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR QMQQQVQQRT 1260
LMMRGQGLNV TPSMVAPAGL PAAMSNPRIP QANAQQFPFP PNYGISQQPD PGFTGATTPQ 1320
SPLMSPRMAH TQSPMMQQSQ ANPAYQPTSD MNGWAQGSMG GNSMFSQQSP PHFGQQANTS 1380
MYSNNMNISV SMATNTGGLS SMNQMTGQMS MTSVTSVPTS GLPSMGPEQV NDPALRGGNL 1440
FPNQLPGMDM IKQEGDASRK YC 1462 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:MGI. GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0003682; F:chromatin binding; IDA:MGI. GO:0004402; F:histone acetyltransferase activity; IEA:InterPro. GO:0005102; F:receptor binding; IDA:MGI. GO:0004871; F:signal transducer activity; IEA:InterPro. GO:0030375; F:thyroid hormone receptor coactivator activity; IDA:MGI. GO:0016573; P:histone acetylation; IEA:GOC. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |