UniProt Accession

 ZDHC6_HUMAN; Q9H6R6; D3DRB6; Q53G45; Q96IV7; Q9H605 

Genbank Protein ID

 AF267740; AK025605; AK026369; AK223086; CH471066; CH471066; BC007213; BC017434 

Genbank Nucleotide ID

 AAL56663.1; BAB15187.1; BAB15462.1; BAD96806.1; EAW49526.1; EAW49528.1; AAH07213.1; AAH17434.1 

Protein Name

 Palmitoyltransferase ZDHHC6 

Protein Synonyms/Alias

 Transmembrane protein H4; Zinc finger DHHC domain-containing protein 6; DHHC-6; Zinc finger protein 376 

Gene Name

 ZDHHC6 

Gene Synonyms/Alias

 ZNF376 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
182	SFGWNTVKIDMSAAR	ubiquitination	[1]
245	IESWIEEKAKDRIQY	ubiquitination	[1]
273	GSRWRNFKQVFTWSG	ubiquitination	[1]
353	EPRIQLQKGEFILAT	ubiquitination	[1, 2, 3]
371	RYWLYGDKILDDSFI	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. 

Sequence Annotation

 ZN_FING 99 149 DHHC-type.  

Keyword

 Acyltransferase; Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; Metal-binding; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 413 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR011511; SH3_2.
 IPR001452; SH3_domain.
 IPR001594; Znf_DHHC_palmitoyltrfase. 

Pfam

 PF07653; SH3_2
 PF01529; zf-DHHC 

SMART

 SM00326; SH3 

PROSITE

 PS50216; ZF_DHHC 

PRINTS