Tag | Content |
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CPLM ID | CPLM-019844 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Interferon-induced transmembrane protein 2 |
Protein Synonyms/Alias | Dispanin subfamily A member 2c; DSPA2c; Fragilis protein 3 |
Gene Name | Ifitm2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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23 | PPSYETIKEEYGVTE | ubiquitination | [1] | 87 | SVKSRDRKMVGDVVG | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53- independent manner. |
Sequence Annotation | MOD_RES 1 1 N-acetylmethionine (By similarity). LIPID 70 70 S-palmitoyl cysteine (By similarity). LIPID 71 71 S-palmitoyl cysteine (By similarity). LIPID 104 104 S-palmitoyl cysteine (By similarity). |
Keyword | Acetylation; Antiviral defense; Cell membrane; Complete proteome; Immunity; Innate immunity; Lipoprotein; Membrane; Palmitate; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 144 AA |
Protein Sequence | MSHNSQAFLS TNAGLPPSYE TIKEEYGVTE LGEPSNSAVV RTTVINMPRE VSVPDHVVWS 60 LFNTLFFNAC CLGFVAYAYS VKSRDRKMVG DVVGAQAYAS TAKCLNISSL IFSILMVIIC 120 IIIFSTTSVV VFQSFAQRTP HSGF 144 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0051607; P:defense response to virus; IDA:MGI. GO:0045087; P:innate immune response; IEA:UniProtKB-KW. GO:0046597; P:negative regulation of viral entry into host cell; IDA:UniProtKB. |
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