CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032416
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 MTHFD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
50RKLAQQIKQEVRQEVacetylation[1, 2, 3]
50RKLAQQIKQEVRQEVubiquitination[4]
88SHSYVLNKTRAAAVVubiquitination[4]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 267 AA 
Protein Sequence
MAATSLMSAL AARLLQPAHS CSLRLRPFHL AAVRNEAVVI SGRKLAQQIK QEVRQEVEEW 60
VASGNKRPHL SVILVGENPA SHSYVLNKTR AAAVVEHIDE RRICNAVSPD KDVDGFHVIN 120
VGRMCLDQYS MLPATPWGVW EIIKRTGIPT LGKNVVVAGR SKNVGMPIAM LLHTDGAHER 180
PGGDATVTIS HRYTPKEQLK KHTILADIVI SAAGVRQKAG YITPVPGGVG PMTVAMLMKN 240
TIIAAKKVLR LEEREVLKSK ELGVATN 267 
Gene Ontology
 GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
 GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro. 
Interpro
 IPR016040; NAD(P)-bd_dom.
 IPR020630; THF_DH/CycHdrlase_cat_dom.
 IPR020867; THF_DH/CycHdrlase_CS.
 IPR020631; THF_DH/CycHdrlase_NAD-bd_dom. 
Pfam
 PF00763; THF_DHG_CYH
 PF02882; THF_DHG_CYH_C 
SMART
  
PROSITE
 PS00767; THF_DHG_CYH_2 
PRINTS