CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041981
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tetratricopeptide repeat domain 7A, isoform CRA_a 
Protein Synonyms/Alias
 Tetratricopeptide repeat protein 7A 
Gene Name
 TTC7A 
Gene Synonyms/Alias
 hCG_17034 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
45ALLEQCLKENHAKIKubiquitination[1]
50CLKENHAKIKDSMPLubiquitination[1]
69EPKMSEAKNYLSSILubiquitination[1]
123DDMSMENKPLYQMRLubiquitination[1]
138LSEAFVIKGLSLERLubiquitination[1, 2]
225LKKGNIVKGMRELREubiquitination[1]
240VLRTVETKATQNFKVubiquitination[3]
246TKATQNFKVMAAKHLubiquitination[1]
292FATQALRKPHLYEGDubiquitination[1, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 824 AA 
Protein Sequence
MVPSSSRTPG FKQSSHHLRL PKCWDYRDDF GKLLLAEALL EQCLKENHAK IKDSMPLLEK 60
NEPKMSEAKN YLSSILNHGR LSPQYMCEAM LILGKLHYVE GSYRDAISMY ARAGIDDMSM 120
ENKPLYQMRL LSEAFVIKGL SLERLPNSIA SRFRLTEREE EVITCFERAS WIAQVFLQEL 180
EKTTNNSTSR HLKGCHPLDY ELTYFLEAAL QSAYVKNLKK GNIVKGMREL REVLRTVETK 240
ATQNFKVMAA KHLAGVLLHS LSEECYWSPL SHPLPEFMGK EESSFATQAL RKPHLYEGDN 300
LYCPKDNIEE ALLLLLISES MATRDVVLSR VPEQEEDRTV SLQNAAAIYD LLSITLGRRG 360
QYVMLSECLE RAMKFAFGEF HLWYQVALSM VACGKSAYAV SLLRECVKLR PSDPTVPLMA 420
AKVCIGSLRW LEEAEHFAMM VISLGEEAGE FLPKGYLALG LTYSLQATDA TLKSKQDELH 480
RKALQTLERA QQLAPSDPQV ILYVSLQLAL VRQISSAMEQ LQEALKVRKD DAHALHLLAL 540
LFSAQKHHQH ALDVVNMAIT EHPENFNLMF TKVKLEQVLK GPEEALVTCR QVLRLWQTLY 600
SFSQLGGLEK DGSFGEGLTM KKQSGMHLTL PDAHDADSGS RRASSIAASR LEEAMSELTM 660
PSSVLKQGPM QLWTTLEQIW LQAAELFMEQ QHLKEAGFCI QEAAGLFPTS HSVLYMRGRL 720
AEVKGNLEEA KQLYKEALTV NPDGVRIMHS LGLMLSRLGH KSLAQKVLRD AVERQSTCHE 780
AWQGLGEVLQ AQGQNEAAVD CFLTALELEA SSPVLPFSII PREL 824 
Gene Ontology
  
Interpro
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat.
 IPR026900; Ttc7. 
Pfam
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS