| Tag | Content |
|---|
| CPLM ID | CPLM-011424 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | GA-binding protein subunit beta-1 |
Protein Synonyms/Alias | GABP subunit beta-1; GABPB-1; GABP subunit beta-2; GABPB-2; Nuclear respiratory factor 2; Transcription factor E4TF1-47; Transcription factor E4TF1-53 |
Gene Name | GABPB1 |
Gene Synonyms/Alias | E4TF1B; GABPB; GABPB2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 8 | MSLVDLGKKLLEAAR | ubiquitination | [1] | | 9 | SLVDLGKKLLEAARA | ubiquitination | [1] | | 100 | HGADVNAKDMLKMTA | ubiquitination | [1] | | 135 | ADVHTQSKFCKTAFD | ubiquitination | [1] | | 392 | MTRLQTNKEAV**** | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. |
Sequence Annotation | REPEAT 5 34 ANK 1.
REPEAT 37 66 ANK 2.
REPEAT 70 99 ANK 3.
REPEAT 103 132 ANK 4.
REPEAT 136 166 ANK 5.
REGION 258 327 Transcription activation and HCFC1 |
Keyword | Alternative splicing; ANK repeat; Complete proteome; Direct protein sequencing; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 395 AA |
Protein Sequence | MSLVDLGKKL LEAARAGQDD EVRILMANGA PFTTDWLGTS PLHLAAQYGH YSTTEVLLRA 60
GVSRDARTKV DRTPLHMAAS EGHASIVEVL LKHGADVNAK DMLKMTALHW ATEHNHQEVV 120
ELLIKYGADV HTQSKFCKTA FDISIDNGNE DLAEILQIAM QNQINTNPES PDTVTIHAAT 180
PQFIIGPGGV VNLTGLVSSE NSSKATDETG VSAVQFGNSS TSVLATLAAL AEASAPLSNS 240
SETPVVATEE VVTAESVDGA IQQVVSSGGQ QVITIVTDGI QLGNLHSIPT SGIGQPIIVT 300
MPDGQQVLTV PATDIAEETV ISEEPPAKRQ CIEIIENRVE SAEIEEREAL QKQLDEANRE 360
AQKYRQQLLK KEQEAEAYRQ KLEAMTRLQT NKEAV 395 |
Gene Ontology | GO:0005634; C:nucleus; IDA:MGI. GO:0046982; F:protein heterodimerization activity; IDA:MGI. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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