CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001356
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein lifeguard 2 
Protein Synonyms/Alias
 Fas apoptotic inhibitory molecule 2; Neural membrane protein 35 
Gene Name
 Faim2 
Gene Synonyms/Alias
 Lfg; Lfg2; Nmp35 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
11GKLSVANKAPGTEGQubiquitination[1]
25QQQANGEKKDAPAVPubiquitination[1]
26QQANGEKKDAPAVPSubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity). 
Sequence Annotation
 MOD_RES 38 38 Phosphotyrosine (By similarity).
 CARBOHYD 191 191 N-linked (GlcNAc...) (Potential).  
Keyword
 Apoptosis; Cell junction; Cell membrane; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 316 AA 
Protein Sequence
MTQGKLSVAN KAPGTEGQQQ ANGEKKDAPA VPSAPPSYEE ATSGEGLKAG AFPQGPTAVP 60
LHPSWAYVDP SSSSGYEGGF PAGHHELFST FSWDDQKVRQ LFIRKVYTIL LVQLLVTLAV 120
VALFTFCDVV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTIFTLSMA 180
YLTGMLSSYY NTTSVLLCLG ITALVCLSVT IFSFQTKFDF TSCHGVLFVL LMTLFFSGLL 240
LAILLPFQYV PWLHAVYAVL GAGVFTLFLA FDTQLLMGNR RHSLSPEEYI FGALNIYLDI 300
IYIFTFFLQL FGTNRE 316 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0021681; P:cerebellar granular layer development; ISS:UniProtKB.
 GO:0021702; P:cerebellar Purkinje cell differentiation; ISS:UniProtKB.
 GO:0043523; P:regulation of neuron apoptotic process; ISS:UniProtKB. 
Interpro
 IPR006214; Bax_inhibitor_1-related. 
Pfam
 PF01027; Bax1-I 
SMART
  
PROSITE
  
PRINTS