CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014475
UniProt Accession
Genbank Protein ID
 U52103 
Genbank Nucleotide ID
Protein Name
 Dihydropyrimidinase-related protein 4 
Protein Synonyms/Alias
 DRP-4; Collapsin response mediator protein 3; CRMP-3; UNC33-like phosphoprotein 4; ULIP-4 
Gene Name
 Dpysl4 
Gene Synonyms/Alias
 Crmp3; Ulip4 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
337TAQKAVGKDNFTLIPubiquitination[1]
464AGRFIPRKTFPDFVYubiquitination[1]
503HEVMLPAKPGSGTQAubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 564 AA 
Protein Sequence
IPRITSDRLL IKGGKIVNDD QSFHADLYVE DGLIKQIGEN LIVPGGIKTI DAHGLMVLPG 60
GVDVHTRLQM PVLGMTPADD FCQGTKAALA GGTTMILDHV FPDAGVSLLA AYEQWRERAD 120
SAACCDYSLH VDIPRWHEST KEELEALVRD KGVNSFLVFM AYKDRCQCTD GQIYEIFSLI 180
RDLGAVAQVH AENGDIVEEE QKRLLEQGIT GPEGHVLSHP EEVEAEAVYR AVTIAKQANC 240
PLYITKVMSK GAADMVAQAK RRGVVVFGEP ITASLGTDGS HYWSKNWAKA AAFVTSPPIN 300
PDPTTADHLT SLLSSGDLQV TGSAHCTFTT AQKAVGKDNF TLIPEGINGI EERMSVVWEK 360
CVASGKMDEN EFVAVTSTNA AKIFNFYPRK GRVAVGSDAD LVIWNPRATK VISAKSHNLN 420
VEYNIFEGVE CRGMPTVVIS QGRVVLEDGN LLVTPGAGRF IPRKTFPDFV YKRIKARNRL 480
AEIHGVPRGL YDGPVHEVML PAKPGSGTQA RASCPGKISV PPVRNLHQSG FSLSGSQADD 540
HIARRTAQKI MAPPGGRSNI TSLS 564 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016812; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; IEA:InterPro.
 GO:0048666; P:neuron development; IEP:RGD.
 GO:0006208; P:pyrimidine nucleobase catabolic process; IEA:InterPro. 
Interpro
 IPR006680; Amidohydro_1.
 IPR011778; Hydantoinase/dihydroPyrase.
 IPR011059; Metal-dep_hydrolase_composite. 
Pfam
 PF01979; Amidohydro_1 
SMART
  
PROSITE
  
PRINTS