UniProt Accession

 KHK_MOUSE; P97328; Q91WU8 

Genbank Protein ID

 Y09335; BC013464 

Genbank Nucleotide ID

 CAA70515.1; AAH13464.1 

Protein Name

 Ketohexokinase 

Protein Synonyms/Alias

 Hepatic fructokinase 

Gene Name

 Khk 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
127	VSAKDFEKVDLTRFK	acetylation	[1]
159	RIEEHNAKQPLPQKV	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

  

Sequence Annotation

 NP_BIND 255 258 ATP (By similarity).
 BINDING 15 15 D-fructose (By similarity).
 BINDING 41 41 D-fructose; via amide nitrogen (By
 BINDING 42 42 D-fructose (By similarity).
 BINDING 45 45 D-fructose (By similarity).
 BINDING 108 108 ATP (By similarity).
 BINDING 258 258 D-fructose (By similarity).
 MOD_RES 169 169 Phosphoserine.  

Keyword

 ATP-binding; Carbohydrate metabolism; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 298 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004454; F:ketohexokinase activity; IEA:EC.
 GO:0006000; P:fructose metabolic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR011611; PfkB_dom. 

Pfam

 PF00294; PfkB 

SMART

  

PROSITE

 PS00583; PFKB_KINASES_1
 PS00584; PFKB_KINASES_2 

PRINTS