| Tag | Content |
|---|
| CPLM ID | CPLM-004448 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phenylalanine-4-hydroxylase |
Protein Synonyms/Alias | PAH; Phe-4-monooxygenase |
Gene Name | Pah |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 50 | EEVGALAKVLRLFEE | ubiquitination | [1] | | 74 | SRPSRLNKDEYEFFT | ubiquitination | [1] | | 85 | EFFTYLDKRSKPVLG | ubiquitination | [1] | | 88 | TYLDKRSKPVLGSII | ubiquitination | [1] | | 96 | PVLGSIIKSLRNDIG | ubiquitination | [1] | | 115 | ELSRDKEKNTVPWFP | ubiquitination | [1] | | 150 | DADHPGFKDPVYRAR | ubiquitination | [1] | | 159 | PVYRARRKQFADIAY | ubiquitination | [1] | | 185 | EYTEEERKTWGTVFR | ubiquitination | [1] | | 199 | RTLKALYKTHACYEH | ubiquitination | [1] | | 274 | QYIRHGSKPMYTPEP | ubiquitination | [1] | | 361 | LQYCLSDKPKLLPLE | ubiquitination | [1] | | 363 | YCLSDKPKLLPLELE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | |
Sequence Annotation | DOMAIN 36 114 ACT.
METAL 285 285 Iron (By similarity).
METAL 290 290 Iron (By similarity).
METAL 330 330 Iron (By similarity).
MOD_RES 2 2 N-acetylalanine.
MOD_RES 16 16 Phosphoserine; by PKA (By similarity). |
Keyword | Acetylation; Allosteric enzyme; Complete proteome; Direct protein sequencing; Disease mutation; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Phenylalanine catabolism; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 453 AA |
Protein Sequence | MAAVVLENGV LSRKLSDFGQ ETSYIEDNSN QNGAVSLIFS LKEEVGALAK VLRLFEENEI 60
NLTHIESRPS RLNKDEYEFF TYLDKRSKPV LGSIIKSLRN DIGATVHELS RDKEKNTVPW 120
FPRTIQELDR FANQILSYGA ELDADHPGFK DPVYRARRKQ FADIAYNYRH GQPIPRVEYT 180
EEERKTWGTV FRTLKALYKT HACYEHNHIF PLLEKYCGFR EDNIPQLEDV SQFLQTCTGF 240
RLRPVAGLLS SRDFLGGLAF RVFHCTQYIR HGSKPMYTPE PDICHELLGH VPLFSDRSFA 300
QFSQEIGLAS LGAPDEYIEK LATIYWFTVE FGLCKEGDSI KAYGAGLLSS FGELQYCLSD 360
KPKLLPLELE KTACQEYTVT EFQPLYYVAE SFNDAKEKVR TFAATIPRPF SVRYDPYTQR 420
VEVLDNTQQL KILADSINSE VGILCHALQK IKS 453 |
Gene Ontology | GO:0016597; F:amino acid binding; IEA:InterPro. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0004505; F:phenylalanine 4-monooxygenase activity; IMP:MGI. GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |