CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002545
UniProt Accession
Genbank Protein ID
 M17169 
Genbank Nucleotide ID
Protein Name
 78 kDa glucose-regulated protein 
Protein Synonyms/Alias
 GRP-78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP 
Gene Name
 HSPA5 
Gene Synonyms/Alias
 GRP78 
Created Date
 July 27, 2013 
Organism
 Mesocricetus auratus (Golden hamster) 
NCBI Taxa ID
 10036 
Lysine Modification
Position
Peptide
Type
References
573ESYAYSLKNQIGDKEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. 
Sequence Annotation
 MOTIF 651 654 Prevents secretion from ER.
 MOD_RES 160 160 Nitrated tyrosine (By similarity).
 MOD_RES 166 166 Phosphothreonine (By similarity).
 MOD_RES 518 518 Phosphothreonine (By similarity).
 MOD_RES 571 571 Phosphoserine (By similarity).
 MOD_RES 585 585 N6,N6,N6-trimethyllysine; by METTL21A; in
 MOD_RES 649 649 Phosphoserine (By similarity).  
Keyword
 ATP-binding; Cytoplasm; Endoplasmic reticulum; Methylation; Nitration; Nucleotide-binding; Phosphoprotein; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 654 AA 
Protein Sequence
MKFPMVAAAL LLLCAVRAEE EDKKEDVGTV VGIDLGTTYS CVGVFKNGRV EIIANDQGNR 60
ITPSYVAFTP EGERLIGDAA KNQLTSNPEN TVFDAKRLIG RTWNDPSVQQ DIKFLPFKVV 120
EKKTKPYIQV DIGGGQTKTF APEEISAMVL TKMKETAEAY LGKKVTHAVV TVPAYFNDAQ 180
RQATKDAGTI AGLNVMRIIN EPTAAAIAYG LDKREGEKNI LVFDLGGGTF DVSLLTIDNG 240
VFEVVATNGD THLGGEDFDQ RVMEHFIKLY KKKTGKDVRK DNRAVQKLRR EVEKAKRALS 300
SQHQARIEIE SFFEGEDFSE TLTRAKFEEL NMDLFRSTMK PVQKVLEDSD LKKSDIDEIV 360
LVGGSTRIPK IQQLVKEFFN GKEPSRGINP DEAVAYGAAV QAGVLSGDQD TGDLVLLDVC 420
PLTLGIETVG GVMTKLIPRN TVVPTKKSQI FSTASDNQPT VTIKVYEGER PLTKDNHLLG 480
TFDLTGIPPA PRGVPQIEVT FEIDVNGILR VTAEDKGTGN KNKITITNDQ NRLTPEEIER 540
MVNDAEKFAE EDKKLKERID TRNELESYAY SLKNQIGDKE KLGGKLSSED KETMEKAVEE 600
KIEWLESHQD ADIEDFKAKK KELEEIVQPI ISKLYGSAGP PPTGEEDTSE KDEL 654 
Gene Ontology
 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:UniProtKB.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IDA:UniProtKB. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00014; ER_TARGET
 PS00297; HSP70_1
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.