UniProt Accession

 CD59_HUMAN; P13987 

Genbank Protein ID

 M27909; M95708; X16447; X17198; M34671; M84345; M84349; M84346; M84348; Z14113; Z14114; Z14115; BT007104; BC001506 

Genbank Nucleotide ID

 AAA60543.1; AAA60957.1; CAA34467.1; CAA35059.1; AAA51952.1; AAA88793.1; AAA88793.1; AAA88793.1; CAA78486.1; CAA78486.1; CAA78486.1; AAP35768.1; AAH01506.1 

Protein Name

 CD59 glycoprotein 

Protein Synonyms/Alias

 1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD59 

Gene Name

 CD59 

Gene Synonyms/Alias

 MIC11; MIN1; MIN2; MIN3; MSK21 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	QVYNKCWKFEHCNFN	glycation	[1]

Reference

 [1] Molecular basis for a link between complement and the vascular complications of diabetes.
 Acosta J, Hettinga J, Flückiger R, Krumrei N, Goldfine A, Angarita L, Halperin J.
 Proc Natl Acad Sci U S A. 2000 May 9;97(10):5450-5. [PMID: 10805801] 

Functional Description

 Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. 

Sequence Annotation

 DOMAIN 26 108 UPAR/Ly6.
 LIPID 102 102 GPI-anchor amidated asparagine.
 CARBOHYD 43 43 N-linked (GlcNAc...).
 CARBOHYD 66 66 N-linked (Glc) (glycation).
 CARBOHYD 69 69 N-linked (Glc) (glycation).
 CARBOHYD 76 76 O-linked (GlcNAc...) (Probable).
 CARBOHYD 77 77 O-linked (GlcNAc...) (Probable).
 DISULFID 28 51
 DISULFID 31 38
 DISULFID 44 64
 DISULFID 70 88
 DISULFID 89 94  

Keyword

 3D-structure; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycation; Glycoprotein; GPI-anchor; Hereditary hemolytic anemia; Lipoprotein; Membrane; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 128 AA 

Protein Sequence

Gene Ontology

 GO:0031362; C:anchored to external side of plasma membrane; IDA:MGI.
 GO:0043218; C:compact myelin; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0007596; P:blood coagulation; TAS:ProtInc.
 GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
 GO:0001971; P:negative regulation of activation of membrane attack complex; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0042102; P:positive regulation of T cell proliferation; IEA:Compara. 

Interpro

 IPR018363; CD59_antigen_CS.
 IPR027101; CD59_glyco.
 IPR016054; LY6_UPA_recep-like.
 IPR001526; LY6_UPAR. 

Pfam

 PF00021; UPAR_LY6 

SMART

 SM00134; LU 

PROSITE

 PS00983; LY6_UPAR 

PRINTS