UniProt Accession

 MPP7_HUMAN; Q5T2T1; B2RCC9; B5MDZ3; D3DRW3; Q5T2T0; Q8IY28 

Genbank Protein ID

 AK315046; AL390866; AL355501; AL391423; AL390866; AL355501; AL391423; AL355501; AL390866; AL391423; AL355501; AL390866; AL391423; AL391423; AL355501; AL390866; AL391423; AL355501; AL390866; CH471072; CH471072; BC038105 

Genbank Nucleotide ID

 BAG37526.1; CAI12708.1; CAI12708.1; CAI12708.1; CAI12709.1; CAI12709.1; CAI12709.1; CAI13640.1; CAI13640.1; CAI13640.1; CAI13641.1; CAI13641.1; CAI13641.1; CAI17344.1; CAI17344.1; CAI17344.1; CAI17345.1; CAI17345.1; CAI17345.1; EAW86045.1; EAW86047.1; AAH38105.1 

Protein Name

 MAGUK p55 subfamily member 7 

Protein Synonyms/Alias

  

Gene Name

 MPP7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
62	EKLHYYEKQSPVPIL	ubiquitination	[1]
387	GLNELKRKLLISDTQ	ubiquitination	[2, 3]
433	ETDVQNNKFIEYGEY	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. 

Sequence Annotation

 DOMAIN 10 65 L27 1.
 DOMAIN 67 122 L27 2.
 DOMAIN 139 220 PDZ.
 DOMAIN 228 298 SH3.
 DOMAIN 368 560 Guanylate kinase-like.
 MOD_RES 409 409 Phosphoserine.  

Keyword

 3D-structure; Cell junction; Complete proteome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH3 domain; Tight junction. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 576 AA 

Protein Sequence

Gene Ontology

 GO:0097025; C:MPP7-DLG1-LIN7 complex; IDA:BHF-UCL.
 GO:0005923; C:tight junction; IDA:BHF-UCL.
 GO:0032947; F:protein complex scaffold; IDA:BHF-UCL.
 GO:0046982; F:protein heterodimerization activity; IDA:BHF-UCL.
 GO:0035591; F:signaling adaptor activity; NAS:BHF-UCL.
 GO:0030010; P:establishment of cell polarity; TAS:BHF-UCL.
 GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
 GO:0071896; P:protein localization to adherens junction; IMP:BHF-UCL.
 GO:0070830; P:tight junction assembly; IDA:BHF-UCL. 

Interpro

 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR004172; L27.
 IPR014775; L27_C.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 

Pfam

 PF00625; Guanylate_kin
 PF02828; L27
 PF00595; PDZ
 PF07653; SH3_2 

SMART

 SM00072; GuKc
 SM00569; L27
 SM00228; PDZ
 SM00326; SH3 

PROSITE

 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS51022; L27
 PS50106; PDZ
 PS50002; SH3 

PRINTS

 PR00452; SH3DOMAIN.