UniProt Accession

 STX3_HUMAN; Q13277; B4DME0; O43750; O43751; Q15360 

Genbank Protein ID

 U32315; X90581; AJ002076; AJ002077; AK297419; AP000640; CH471076; BC007405; BC007429 

Genbank Nucleotide ID

 AAA75303.1; CAA62209.1; CAA05175.1; CAA05176.1; BAG59852.1; EAW73854.1; AAH07405.1; AAH07429.1 

Protein Name

 Syntaxin-3 

Protein Synonyms/Alias

  

Gene Name

 STX3 

Gene Synonyms/Alias

 STX3A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
100	NKLKSMEKHIEEDEV	ubiquitination	[1]
117	SADLRIRKSQHSVLS	acetylation	[2]
159	QLEITGKKTTDEELE	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 

Functional Description

 Potentially involved in docking of synaptic vesicles at presynaptic active zones. 

Sequence Annotation

 DOMAIN 191 253 t-SNARE coiled-coil homology.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Membrane; Neurotransmitter transport; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 289 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:HGNC.
 GO:0042582; C:azurophil granule; IDA:UniProtKB.
 GO:0005911; C:cell-cell junction; IDA:UniProtKB.
 GO:0030426; C:growth cone; ISS:HGNC.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031201; C:SNARE complex; ISS:HGNC.
 GO:0042581; C:specific granule; IDA:UniProtKB.
 GO:0050544; F:arachidonic acid binding; ISS:HGNC.
 GO:0006944; P:cellular membrane fusion; IEA:Compara.
 GO:0034599; P:cellular response to oxidative stress; IDA:BHF-UCL.
 GO:0006887; P:exocytosis; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0031175; P:neuron projection development; ISS:HGNC.
 GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW. 

Interpro

 IPR015708; Syntaxin-3.
 IPR006012; Syntaxin/epimorphin_CS.
 IPR006011; Syntaxin_N.
 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom. 

Pfam

 PF05739; SNARE
 PF00804; Syntaxin 

SMART

 SM00503; SynN
 SM00397; t_SNARE 

PROSITE

 PS00914; SYNTAXIN
 PS50192; T_SNARE 

PRINTS