CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015507
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neurobeachin-like protein 2 
Protein Synonyms/Alias
  
Gene Name
 NBEAL2 
Gene Synonyms/Alias
 KIAA0540; UNQ253/PRO290 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
939GLVLPLGKSSEERMEubiquitination[1]
1532EWRHFIDKQVQPTMSubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. 
Sequence Annotation
 REPEAT 1515 1555 WD 1.
 DOMAIN 2053 2345 BEACH.
 REPEAT 2457 2499 WD 2.
 REPEAT 2500 2539 WD 3.
 REPEAT 2551 2592 WD 4.
 REPEAT 2685 2724 WD 5.
 MOD_RES 1647 1647 Phosphoserine.
 MOD_RES 1867 1867 Phosphothreonine.
 MOD_RES 2739 2739 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Phosphoprotein; Polymorphism; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2754 AA 
Protein Sequence
MAASERLYEL WLLYYAQKDL GYLQQWLKAF VGAFKKSISL SSLEPRRPEE AGAEVPLLPL 60
DELHVLAEQL HQADLEQALL LLKLFIILCR NLENIEAGRG QVLVPRVLAL LTKLVAELKG 120
CPPPQGRGTQ LENVALHALL LCEGLFDPYQ TWRRQRSGEV ISSKEKSKYK FPPAALPQEF 180
SAFFQESLQN ADHLPPILLL RLIHLFCAVL AGGKENGQMA VSDGSVKGLL SVVRGWSRGP 240
APDPCLVPLA LEALVGAVHV LHASRAPPRG PELRALLESY FHVLNADWPA GLSSGPEEAL 300
VTLRVSMLDA IPMMLACEDR PVLQATFLSN NCFEHLTRLI QNSKLYLQSR APPEGDSDLA 360
TRLLTEPDVQ KVLDQDTDAI AVHVVRVLTC IMSDSPSAKE VFKERIGYPH LQEVLQSHGP 420
PTHRLLQELL NMAVEGDHSM CPPPPIRNEQ PVLVLAQWLP SLPTAELRLF LAQRLRWLCD 480
SCPASRATCV QAGLVGCLLE TLSTGLALEA RCQEQLLALL QALGRVSIRP MELRHLLRPR 540
PGLDSEPGGA EAGKARHAGA VIRTLSGMAR HQGPARALRY FDLTPSMAGI MVPPVQRWPG 600
PGFTFHAWLC LHPMDTAPTP APTRPLQRKQ LYSFFTSSGS GFEAFFTAAG TLVVAVCTRK 660
EYLTMSLPEV SFADSAWHCV AIVHVPGRRP FSQNLVHVYK DGHLVKTAPL RCPSLSEPFS 720
SCCIGSAGYR TTTTTTGLPT PPVPATLAYT HPALTRSQSV PASTGLGWGS GLVAPLQEGS 780
IDSTLAGTQD TRWGSPTSLE GELGAVAIFH EALQATALRT LCTLGPNETA PFKPEGELHE 840
LSTRLLLHYS PQACKNNICL DLSPSHGLDG RLTGHRVETW DVKDVVNCVG GMGALLPLLE 900
RVAAQPKEAE AGPAETHDLV GPELTSGHNT QGLVLPLGKS SEERMERNAV AAFLLMLRNF 960
LQGHMVNQES LVQCQGPAII GALLRKVPSW AMDMNVLMSA QLLMEQVAAE GSGPLLYLLY 1020
QHLLFNFHLW TLSDFAVRLG HIQYMSSIVR EHRQKLRKKY GVQFILDALR THYSPQRERP 1080
LAADDLRTVQ TSLLGLAREF LVRSLSADDV QVTQTMLSFL AATGDDGQIL RRLQQNERLP 1140
ERSRQRLRLR ECGLQGLVAC LPEGTVSPQL CQGLYKLFLG AGSGNTAGGG GSSGTLTPAS 1200
QPGTPSPLDG PRPFPAAPGR HSSSLSNVLE DGSLPEPTIS GDDTSNTSNP QQTSEEELCN 1260
LLTNVLFSVT WRGVEGSDEA AWRERGQVFS VLTQLGASAT LVRPPDCIKR SLLEMMLESA 1320
LTDIKEAPVG VLASLTQQAL WLLRLLQDFL CAEGHGNQEL WSEKLFEGVC SLLDRLGAWP 1380
HLANGTADLR EMAQIGLRLV LGYILLEDPQ LHAQAYVRLH MLLQTAVPAR REEACYVLSK 1440
LEAALGRVLN TSSLESATDE AGSPLAAAAA AAAAERCSWL VPLVRTLLDR AYEPLGLQWG 1500
LPSLPPTNGS PTFFEDFQAF CATPEWRHFI DKQVQPTMSQ FEMDTYAKSH DLMSGFWNAC 1560
YDMLMSSGQR RQWERAQSRR AFQELVLEPA QRRARLEGLR YTAVLKQQAT QHSMALLHWG 1620
ALWRQLASPC GAWALRDTPI PRWKLSSAET YSRMRLKLVP NHHFDPHLEA SALRDNLGEV 1680
PLTPTEEASL PLAVTKEAKV STPPELLQED QLGEDELAEL ETPMEAAELD EQREKLVLSA 1740
ECQLVTVVAV VPGLLEVTTQ NVYFYDGSTE RVETEEGIGY DFRRPLAQLR EVHLRRFNLR 1800
RSALELFFID QANYFLNFPC KVGTTPVSSP SQTPRPQPGP IPPHTQVRNQ VYSWLLRLRP 1860
PSQGYLSSRS PQEMLRASGL TQKWVQREIS NFEYLMQLNT IAGRTYNDLS QYPVFPWVLQ 1920
DYVSPTLDLS NPAVFRDLSK PIGVVNPKHA QLVREKYESF EDPAGTIDKF HYGTHYSNAA 1980
GVMHYLIRVE PFTSLHVQLQ SGRFDCSDRQ FHSVAAAWQA RLESPADVKE LIPEFFYFPD 2040
FLENQNGFDL GCLQLTNEKV GDVVLPPWAS SPEDFIQQHR QALESEYVSA HLHEWIDLIF 2100
GYKQRGPAAE EALNVFYYCT YEGAVDLDHV TDERERKALE GIISNFGQTP CQLLKEPHPT 2160
RLSAEEAAHR LARLDTNSPS IFQHLDELKA FFAEVVSDGV PLVLALVPHR QPHSFITQGS 2220
PDLLVTVSAS GLLGTHSWLP YDRNISNYFS FSKDPTMGSH KTQRLLSGPW VPGSGVSGQA 2280
LAVAPDGKLL FSGGHWDGSL RVTALPRGKL LSQLSCHLDV VTCLALDTCG IYLISGSRDT 2340
TCMVWRLLHQ GGLSVGLAPK PVQVLYGHGA AVSCVAISTE LDMAVSGSED GTVIIHTVRR 2400
GQFVAALRPL GATFPGPIFH LALGSEGQIV VQSSAWERPG AQVTYSLHLY SVNGKLRASL 2460
PLAEQPTALT VTEDFVLLGT AQCALHILQL NTLLPAAPPL PMKVAIRSVA VTKERSHVLV 2520
GLEDGKLIVV VAGQPSEVRS SQFARKLWRS SRRISQVSSG ETEYNPTEAR 2570 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0030220; P:platelet formation; IMP:UniProtKB. 
Interpro
 IPR016024; ARM-type_fold.
 IPR000409; BEACH_dom.
 IPR008985; ConA-like_lec_gl_sf.
 IPR026916; NBEAL.
 IPR023362; PH-BEACH_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF02138; Beach
 PF00400; WD40 
SMART
 SM01026; Beach
 SM00320; WD40 
PROSITE
 PS50197; BEACH
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS