Tag | Content |
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CPLM ID | CPLM-015507 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Neurobeachin-like protein 2 |
Protein Synonyms/Alias | |
Gene Name | NBEAL2 |
Gene Synonyms/Alias | KIAA0540; UNQ253/PRO290 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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939 | GLVLPLGKSSEERME | ubiquitination | [1] | 1532 | EWRHFIDKQVQPTMS | ubiquitination | [1] |
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Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. |
Sequence Annotation | REPEAT 1515 1555 WD 1. DOMAIN 2053 2345 BEACH. REPEAT 2457 2499 WD 2. REPEAT 2500 2539 WD 3. REPEAT 2551 2592 WD 4. REPEAT 2685 2724 WD 5. MOD_RES 1647 1647 Phosphoserine. MOD_RES 1867 1867 Phosphothreonine. MOD_RES 2739 2739 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Phosphoprotein; Polymorphism; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2754 AA |
Protein Sequence | MAASERLYEL WLLYYAQKDL GYLQQWLKAF VGAFKKSISL SSLEPRRPEE AGAEVPLLPL 60 DELHVLAEQL HQADLEQALL LLKLFIILCR NLENIEAGRG QVLVPRVLAL LTKLVAELKG 120 CPPPQGRGTQ LENVALHALL LCEGLFDPYQ TWRRQRSGEV ISSKEKSKYK FPPAALPQEF 180 SAFFQESLQN ADHLPPILLL RLIHLFCAVL AGGKENGQMA VSDGSVKGLL SVVRGWSRGP 240 APDPCLVPLA LEALVGAVHV LHASRAPPRG PELRALLESY FHVLNADWPA GLSSGPEEAL 300 VTLRVSMLDA IPMMLACEDR PVLQATFLSN NCFEHLTRLI QNSKLYLQSR APPEGDSDLA 360 TRLLTEPDVQ KVLDQDTDAI AVHVVRVLTC IMSDSPSAKE VFKERIGYPH LQEVLQSHGP 420 PTHRLLQELL NMAVEGDHSM CPPPPIRNEQ PVLVLAQWLP SLPTAELRLF LAQRLRWLCD 480 SCPASRATCV QAGLVGCLLE TLSTGLALEA RCQEQLLALL QALGRVSIRP MELRHLLRPR 540 PGLDSEPGGA EAGKARHAGA VIRTLSGMAR HQGPARALRY FDLTPSMAGI MVPPVQRWPG 600 PGFTFHAWLC LHPMDTAPTP APTRPLQRKQ LYSFFTSSGS GFEAFFTAAG TLVVAVCTRK 660 EYLTMSLPEV SFADSAWHCV AIVHVPGRRP FSQNLVHVYK DGHLVKTAPL RCPSLSEPFS 720 SCCIGSAGYR TTTTTTGLPT PPVPATLAYT HPALTRSQSV PASTGLGWGS GLVAPLQEGS 780 IDSTLAGTQD TRWGSPTSLE GELGAVAIFH EALQATALRT LCTLGPNETA PFKPEGELHE 840 LSTRLLLHYS PQACKNNICL DLSPSHGLDG RLTGHRVETW DVKDVVNCVG GMGALLPLLE 900 RVAAQPKEAE AGPAETHDLV GPELTSGHNT QGLVLPLGKS SEERMERNAV AAFLLMLRNF 960 LQGHMVNQES LVQCQGPAII GALLRKVPSW AMDMNVLMSA QLLMEQVAAE GSGPLLYLLY 1020 QHLLFNFHLW TLSDFAVRLG HIQYMSSIVR EHRQKLRKKY GVQFILDALR THYSPQRERP 1080 LAADDLRTVQ TSLLGLAREF LVRSLSADDV QVTQTMLSFL AATGDDGQIL RRLQQNERLP 1140 ERSRQRLRLR ECGLQGLVAC LPEGTVSPQL CQGLYKLFLG AGSGNTAGGG GSSGTLTPAS 1200 QPGTPSPLDG PRPFPAAPGR HSSSLSNVLE DGSLPEPTIS GDDTSNTSNP QQTSEEELCN 1260 LLTNVLFSVT WRGVEGSDEA AWRERGQVFS VLTQLGASAT LVRPPDCIKR SLLEMMLESA 1320 LTDIKEAPVG VLASLTQQAL WLLRLLQDFL CAEGHGNQEL WSEKLFEGVC SLLDRLGAWP 1380 HLANGTADLR EMAQIGLRLV LGYILLEDPQ LHAQAYVRLH MLLQTAVPAR REEACYVLSK 1440 LEAALGRVLN TSSLESATDE AGSPLAAAAA AAAAERCSWL VPLVRTLLDR AYEPLGLQWG 1500 LPSLPPTNGS PTFFEDFQAF CATPEWRHFI DKQVQPTMSQ FEMDTYAKSH DLMSGFWNAC 1560 YDMLMSSGQR RQWERAQSRR AFQELVLEPA QRRARLEGLR YTAVLKQQAT QHSMALLHWG 1620 ALWRQLASPC GAWALRDTPI PRWKLSSAET YSRMRLKLVP NHHFDPHLEA SALRDNLGEV 1680 PLTPTEEASL PLAVTKEAKV STPPELLQED QLGEDELAEL ETPMEAAELD EQREKLVLSA 1740 ECQLVTVVAV VPGLLEVTTQ NVYFYDGSTE RVETEEGIGY DFRRPLAQLR EVHLRRFNLR 1800 RSALELFFID QANYFLNFPC KVGTTPVSSP SQTPRPQPGP IPPHTQVRNQ VYSWLLRLRP 1860 PSQGYLSSRS PQEMLRASGL TQKWVQREIS NFEYLMQLNT IAGRTYNDLS QYPVFPWVLQ 1920 DYVSPTLDLS NPAVFRDLSK PIGVVNPKHA QLVREKYESF EDPAGTIDKF HYGTHYSNAA 1980 GVMHYLIRVE PFTSLHVQLQ SGRFDCSDRQ FHSVAAAWQA RLESPADVKE LIPEFFYFPD 2040 FLENQNGFDL GCLQLTNEKV GDVVLPPWAS SPEDFIQQHR QALESEYVSA HLHEWIDLIF 2100 GYKQRGPAAE EALNVFYYCT YEGAVDLDHV TDERERKALE GIISNFGQTP CQLLKEPHPT 2160 RLSAEEAAHR LARLDTNSPS IFQHLDELKA FFAEVVSDGV PLVLALVPHR QPHSFITQGS 2220 PDLLVTVSAS GLLGTHSWLP YDRNISNYFS FSKDPTMGSH KTQRLLSGPW VPGSGVSGQA 2280 LAVAPDGKLL FSGGHWDGSL RVTALPRGKL LSQLSCHLDV VTCLALDTCG IYLISGSRDT 2340 TCMVWRLLHQ GGLSVGLAPK PVQVLYGHGA AVSCVAISTE LDMAVSGSED GTVIIHTVRR 2400 GQFVAALRPL GATFPGPIFH LALGSEGQIV VQSSAWERPG AQVTYSLHLY SVNGKLRASL 2460 PLAEQPTALT VTEDFVLLGT AQCALHILQL NTLLPAAPPL PMKVAIRSVA VTKERSHVLV 2520 GLEDGKLIVV VAGQPSEVRS SQFARKLWRS SRRISQVSSG ETEYNPTEAR 2570 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB. GO:0030220; P:platelet formation; IMP:UniProtKB. |
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PROSITE | |
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