CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025012
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA polymerase 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
323DIECAGRKGIFPEPEubiquitination[1]
414ISRAQTLKVQTFPFLubiquitination[1, 2]
674PTGDEFVKTSVRKGLubiquitination[1, 2]
764TKQLVESKYTVENGYubiquitination[1, 2]
832FPYLLISKKRYAGLLubiquitination[1, 2]
911ISQLVITKELTRAASubiquitination[1]
923AASDYAGKQAHVELAubiquitination[1]
935ELAERMRKRDPGSAPubiquitination[1]
1024RKTVLTGKVGGLLAFubiquitination[1]
1033GGLLAFAKRRNCCIGubiquitination[1, 2]
1065RESELYQKEVSHLNAubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 DNA replication; DNA-binding; DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1133 AA 
Protein Sequence
MDGKRRPGPG PGVPPKRARG GLWDDDDAPR PSQFEEDLAL MEEMEAEHRL QEQEEEELQS 60
VLEGVADGQV PPSAIDPRWL RPTPPALDPQ TEPLIFQQLE IDHYVGPAQP VPGGPPPSHG 120
SVPVLRAFGV TDEGFSVCCH IHGFAPYFYT PAPPGFGPEH MGDLQRELNL AISRDSRGGR 180
ELTGPAVLAV ELCSRESMFG YHGHGPSPFL RITVALPRLV APARRLLEQG IRVAGLGTPS 240
FAPYEANVDF EIRFMVDTDI VGCNWLELPA GKYALRLKEK ATQCQLEADV LWSDVVSHPP 300
EGPWQRIAPL RVLSFDIECA GRKGIFPEPE RDPVIQICSL GLRWGEPEPF LRLALTLRPC 360
APILGAKVQS YEKEEDLLQA WSTFIRIMDP DVITGYNIQN FDLPYLISRA QTLKVQTFPF 420
LGRVAGLCSN IRDSSFQSKQ TGRRDTKVVS MVGRVQMDML QVLLREYKLR SYTLNAVSFH 480
FLGEQKEDVQ HSIITDLQNG NDQTRRRLAV YCLKDAYLPL RLLERLMVLV NAVEMARVTG 540
VPLSYLLSRG QQVKVVSQLL RQAMHEGLLM PVVKSEGGED YTGATVIGPL KGVRPQDRAG 600
AAWELLALTP GRGCSPPRYY DVPIATLGFS SLYPSIMMAH NLCYTTLLRP GTAQKLGLTE 660
DQFIRTPTGD EFVKTSVRKG LLPQILENLL SARKRAKAEL AKETDPLRRQ VLDGRQLGLK 720
VSANSVYGFT GAQVGKLPCL EISQSVTGFG RQMIEKTKQL VESKYTVENG YSTSAKVVYG 780
DTDSVMCRFG VSSVAEAMAL GREAADWVSG HFPSPIRLEF EKVYFPYLLI SKKRYAGLLF 840
SSRPDAHDRM DCKGLEAVRR DNCPLVANLV TASLRRLLID RDPEGAVAHA QDVISDLLCN 900
RIDISQLVIT KELTRAASDY AGKQAHVELA ERMRKRDPGS APSLGDRVPY VIISAAKGVA 960
AYMKSEDPLF VLEHSLPIDT QYYLEQQLAK PLLRIFEPIL GEGRAEAVLL RGDHTRRKTV 1020
LTGKVGGLLA FAKRRNCCIG CRTVLSHQGA VCEFCQPRES ELYQKEVSHL NALEERFSRL 1080
WTQYQRCQGS LHEDVICTSR DCPIFYMRKK VRKDLEDQEQ LLRRFGPPGP EAW 1133 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW. 
Interpro
 IPR006172; DNA-dir_DNA_pol_B.
 IPR017964; DNA-dir_DNA_pol_B_CS.
 IPR006133; DNA-dir_DNA_pol_B_exonuc.
 IPR006134; DNA-dir_DNA_pol_B_multi_dom.
 IPR004578; DNA-dir_DNA_pol_B_pol2.
 IPR023211; DNA_pol_palm_dom.
 IPR012337; RNaseH-like_dom.
 IPR025687; Znf-C4pol. 
Pfam
 PF00136; DNA_pol_B
 PF03104; DNA_pol_B_exo1
 PF14260; zf-C4pol 
SMART
 SM00486; POLBc 
PROSITE
 PS00116; DNA_POLYMERASE_B 
PRINTS
 PR00106; DNAPOLB.