CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040869
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Microtubule-associated serine/threonine-protein kinase 4 
Protein Synonyms/Alias
  
Gene Name
 MAST4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
841TGGAYEVKQHRFFRSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2626 AA 
Protein Sequence
MGEKVSEAPE PVPRGCSGHG SRTPASALVA ASSPGASSAE SSSGSETLSE EGEPGGFSRE 60
HQPPPPPPLG GTLGARAPAA WAPASVLLER GVLALPPPLP GGAVPPAPRG SSASQEEQDE 120
ELDHILSPPP MPFRKCSNPD VASGPGKSLK YKRQLSEDGR QLRRGSLGGA LTGRYLLPNP 180
VAGQAWPASA ETSNLVRMRS QALGQSAPSL TASLKELSLP RRGSFCRTSN RKSLIGNGQS 240
PALPRPHSPL SAHAGNSPQD SPRNFSPSAS AHFSFARSLN RTDGRRWSLA SLPSSGYGTN 300
TPSSTVSSSC SSQEKLHQLP YQPTPDELHF LSKHFCTTES IATENRCRNT PMRPRSRSLS 360
PGRSPACCDH EIIMMNHVYK ERFPKATAQM EERLKEIITS YSPDNVLPLA DGVLSFTHHQ 420
IIELARDCLD KSHQGLITSR YFLELQHKLD KLLQEAHDRS ESGELAFIKQ LVRKILIVIA 480
RPARLLECLE FDPEEFYYLL EAAEGHAKEG QGIKTDIPRY IISQLGLNKD PLEEMAHLGN 540
YDSGTAETPE TDESVSSSNA SLKLRRKPRE SDFETIKLIS NGAYGAVYFV RHKESRQRFA 600
MKKINKQNLI LRNQIQQAFV ERDILTFAEN PFVVSMYCSF ETRRHLCMVM EYVEGGDCAT 660
LMKNMGPLPV DMARMYFAET VLALEYLHNY GIVHRDLKPD NLLVTSMGHI KLTDFGLSKV 720
GLMSMTTNLY EGHIEKDARE FLDKQVCGTP EYIAPEVILR QGYGKPVDWW AMGIILYEFL 780
VGCVPFFGDT PEELFGQVIS DEINWPEKDE APPPDAQDLI TLLLRQNPLE RLGTGGAYEV 840
KQHRFFRSLD WNSLLRQKAE FIPQLESEDD TSYFDTRSEK YHHMETEEED DTNDEDFNVE 900
IRQFSSCSHR FSKVFSSIDR ITQNSAEEKE DSVDKTKSTT LPSTETLSWS SEYSEMQQLS 960
TSNSSDTESN RHKLSSGLLP KLAISTEGEQ DEAASCPGDP HEEPGKPALP PEECAQEEPE 1020
VTTPASTISS STLSVGSFSE HLDQINGRSE CVDSTDNSSK PSSEPASHMA RQRLESTEKK 1080
KISGKVTKSL SASALSLMIP GDMFAVSPLG SPMSPHSLSS DPSSSRDSSP SRDSSAASAS 1140
PHQPIVIHSS GKNYGFTIRA IRVYVGDSDI YTVHHIVWNV EEGSPACQAG LKAGDLITHI 1200
NGEPVHGLVH TEVIELLLKS GNKVSITTTP FENTSIKTGP ARRNSYKSRM VRRSKKSKKK 1260
ESLERRRSLF KKLAKQPSPL LHTSRSFSCL NRSLSSGESL PGSPTHSLSP RSPTPSYRST 1320
PDFPSGTNSS QSSSPSSSAP NSPAGSGHIR PSTLHGLAPK LGGQRYRSGR RKSAGNIPLS 1380
PLARTPSPTP QPTSPQRSPS PLLGHSLGNS KIAQAFPSKM HSPPTIVRHI VRPKSAEPPR 1440
SPLLKRVQSE EKLSPSYGSD KKHLCSRKHS LEVTQEEVQR EQSQREAPLQ SLDENVCDVP 1500
PLSRARPVEQ GCLKRPVSRK VGRQESVDDL DRDKLKAKVV VKKADGFPEK QESHQKSHGP 1560
GSDLENFALF KLEEREKKVY PKAVERSSTF ENKASMQEAP PLGSLLKDAL HKQASVRASE 1620
GAMSDGRVPA EHRQGGGDFR RAPAPGTLQD GLCHSLDRGI SGKGEGTEKS SQAKELLRCE 1680
KLDSKLANID YLRKKMSLED KEDNLCPVLK PKMTAGSHEC LPGNPVRPTG GQQEPPPASE 1740
SRAFVSSTHA AQMSAVSFVP LKALTGRVDS GTEKPGLVAP ESPVRKSPSE YKLEGRSVSC 1800
LKPIEGTLDI ALLSGPQASK TELPSPESAQ SPSPSGDVRA SVPPVLPSSS GKKNDTTSAR 1860
ELSPSSLKMN KSYLLEPWFL PPSRGLQNSP AVSLPDPEFK RDRKGPHPTA RSPGTVMESN 1920
PQQREGSSPK HQDHTTDPKL LTCLGQNLHS PDLARPRCPL PPEASPSREK PGLRESSERG 1980
PPTARSERSA ARADTCREPS MELCFPETAK TSDNSKNLLS VGRTHPDFYT QTQAMEKAWA 2040
PGGKTNHKDG PGEARPPPRD NSSLHSAGIP CEKELGKVRR GVEPKPEALL ARRSLQPPGI 2100
ESEKSEKLSS FPSLQKDGAK EPERKEQPLQ RHPSSIPPPP LTAKDLSSPA ARQHCSSPSH 2160
ASGREPGAKP STAEPSSSPQ DPPKPVAAHS ESSSHKPRPG PDPGPPKTKH PDRSLSSQKP 2220
SVGATKGKEP ATQSLGGSSR EGKGHSKSGP DVFPATPGSQ NKASDGIGQG EGGPSVPLHT 2280
DRAPLDAKPQ PTSGGRPLEV LEKPVHLPRP GHPGPSEPAD QKLSAVGEKQ TLSPKHPKPS 2340
TVKDCPTLCK QTDNRQTDKS PSQPAANTDR RAEGKKCTEA LYAPAEGDKL EAGLSFVHSE 2400
NRLKGAERPA AGVGKGFPEA RGKGPGPQKP PTEADKPNGM KRSPSATGQS SFRSTALPEK 2460
SLSCSSSFPE TRAGVREASA ASSDTSSAKA AGGMLELPAP SNRDHRKAQP AGEGRTHMTK 2520
SDSLPSFRVS TLPLESHHPD PNTMGGASHR DRALSVTATV GETKGKDPAP AQPPPARKQN 2580
VGRDVTKPSP APNTDRPISL SNEKDFVVRQ RRGKESLRSS PHKKAL 2626 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR015022; MA_Ser/Thr_Kinase_dom.
 IPR023142; MAST_pre-PK_dom.
 IPR001478; PDZ.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF08926; DUF1908
 PF00595; PDZ
 PF00069; Pkinase 
SMART
 SM00228; PDZ
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS50106; PDZ
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS