CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009226
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Agmatinase 
Protein Synonyms/Alias
 Agmatine ureohydrolase; AUH 
Gene Name
 speB 
Gene Synonyms/Alias
 b2937; JW2904 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
104DAREMSEKLQAHAEKacetylation[1]
111KLQAHAEKLLAAGKRacetylation[1]
192GIRTEFDKDNGFTVLacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the formation of putrescine from agmatine. 
Sequence Annotation
 METAL 126 126 Manganese 1 (By similarity).
 METAL 149 149 Manganese 1 (By similarity).
 METAL 149 149 Manganese 2 (By similarity).
 METAL 151 151 Manganese 2 (By similarity).
 METAL 153 153 Manganese 1 (By similarity).
 METAL 230 230 Manganese 1 (By similarity).
 METAL 230 230 Manganese 2 (By similarity).
 METAL 232 232 Manganese 2 (By similarity).  
Keyword
 Complete proteome; Hydrolase; Manganese; Metal-binding; Polyamine biosynthesis; Putrescine biosynthesis; Reference proteome; Spermidine biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 306 AA 
Protein Sequence
MSTLGHQYDN SLVSNAFGFL RLPMNFQPYD SDADWVITGV PFDMATSGRA GGRHGPAAIR 60
QVSTNLAWEH NRFPWNFDMR ERLNVVDCGD LVYAFGDARE MSEKLQAHAE KLLAAGKRML 120
SFGGDHFVTL PLLRAHAKHF GKMALVHFDA HTDTYANGCE FDHGTMFYTA PKEGLIDPNH 180
SVQIGIRTEF DKDNGFTVLD ACQVNDRSVD DVIAQVKQIV GDMPVYLTFD IDCLDPAFAP 240
GTGTPVIGGL TSDRAIKLVR GLKDLNIVGM DVVEVAPAYD QSEITALAAA TLALEMLYIQ 300
AAKKGE 306 
Gene Ontology
 GO:0008783; F:agmatinase activity; IDA:EcoCyc.
 GO:0030145; F:manganese ion binding; IDA:EcoCyc.
 GO:0009446; P:putrescine biosynthetic process; IDA:EcoCyc.
 GO:0033388; P:putrescine biosynthetic process from arginine; IEA:UniProtKB-UniPathway.
 GO:0008295; P:spermidine biosynthetic process; IEA:HAMAP. 
Interpro
 IPR023694; Agmatinase.
 IPR005925; Agmatinase-rel.
 IPR006035; Ureohydrolase.
 IPR023696; Ureohydrolase_domain.
 IPR020855; Ureohydrolase_Mn_BS. 
Pfam
 PF00491; Arginase 
SMART
  
PROSITE
 PS01053; ARGINASE_1
 PS51409; ARGINASE_2 
PRINTS