CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029880
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Copper-transporting ATPase 2 
Protein Synonyms/Alias
  
Gene Name
 Atp7b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
327INPVRNFKSGNSVPQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1347 AA 
Protein Sequence
MPEQERQVTA KEASRKILSK LALPGRPWEQ SMKQSFAFDN VGYEGGLDST SSSPAATDVV 60
NILGMTCHSC VKSIEDRISS LKGIVNIKVS LEQGSATVRY VPSVMNLQQI CLQIEDMGFE 120
ASAAEGKAAS WPSRSSPAQE AVVKLRVEGM TCQSCVSSIE GKIRKLQGVV RIKVSLSNQE 180
AVITYQPYLI QPEDLRDHIC DMGFEAAIKN RTAPLRLGPI DVNKLESTNL KKETVSPVQI 240
SNHFETLGHQ GSYLATLPLR IDGMHYMLSQ RKGVQQTSIS LAEGTGAVLY DPSIVSLDEL 300
RTAVEDMGFE VSVNSETFTI NPVRNFKSGN SVPQTMGDIA GSVQKMAPDT RGLPTHQGPG 360
HSSETPSSPG ATASQKCFVQ IKGMTCASCV SNIERSLQRH AGILSVLVAL MSGKAEVKYD 420
PEIIQSPRIA QLIQDLGFEA SVMEDNTVSE GDIELIITGM TCASCVHNIE SKLTRTNGIT 480
YASVALATSK AHVKFDPEIV GPRDIIKIIE EIGFHASLAQ RNPNAHHLDH KTEIKQWKKS 540
FLCSLVFGIP VMGLMVYMLI PSSTPQETMV LDHNIIPGLS VLNLIFFILC TFVQFLGGWY 600
FYVQAYKSLR HRSANMDVLI VLATTIAYAY SLVILVVAVA EKAEKSPVTF FDTPPMLFVF 660
IALGRWLEHV AKSKTSEALA KLMSLQATEA TVVTLGEDNL ILREEQVPME LVQRGDVIKV 720
VPGGKFPVDG KVLEGNTMAD ESLITGEAMP VTKKPGSIVI AGSINAHGSV LLKATHVGND 780
TTLAQIVKLV EEAQMSKAPI QQLADRFSGY FVPFIIIIST LTLVVWIVIG FVDFGVVQKY 840
FPSPSKHISQ TEVIIRFAFQ TSITVLCIAC PCSLGLATPT AVMVGTGVAA QNGVLIKGGK 900
PLEMAHKIKT VMFDKTGTIT HGVPRVMRFL LLADVATLPL RKVLAVVGTA EASSEHPLGV 960
AVTKYCKEEL GTETLGYSTD FQAVPGCGIS CKVSNVEGIL ARSDLTAHPV GVGNPPTGEG 1020
AGPQTFSVLI GNREWMRRNG LTISSDISDA MTDHEMKGQT AILVAIDGVL CGMIAIADAV 1080
KPEAALAIYT LKSMGVDVAL ITGDNRKTAR AIATQVGINK VFAEVLPSHK VAKVQELQNE 1140
GKKVAMVGDG VNDSPALAQA DVGIAIGTGT DVAIEAADVV LIRNDLLDVV ASIHLSKRTV 1200
RRIRVNLVLA LIYNMVGIPI AAGVFMPIGI VLQPWMGSAA MAASSVSVVL SSLQLKCYRK 1260
PDLERYEAQA HGRMKPLSAS QVSVHIGMDD RRRDSPRATA WDQVSYVSQV SLSSLTSDRL 1320
SRHGGAAEDG GDKWSLLLSD RDEEQCI 1347 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005802; C:trans-Golgi network; IDA:MGI.
 GO:0005507; F:copper ion binding; IEA:InterPro.
 GO:0004008; F:copper-exporting ATPase activity; IDA:MGI.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0006878; P:cellular copper ion homeostasis; IMP:MGI.
 GO:0006882; P:cellular zinc ion homeostasis; IMP:MGI.
 GO:0015680; P:intracellular copper ion transport; IMP:MGI.
 GO:0007595; P:lactation; IMP:MGI. 
Interpro
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR027256; Cation_transp_P-typ_ATPase_IB.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom.
 IPR017969; Heavy-metal-associated_CS.
 IPR006121; HeavyMe-assoc_HMA.
 IPR006122; HMA_Cu_ion-bd. 
Pfam
 PF00122; E1-E2_ATPase
 PF00403; HMA
 PF00702; Hydrolase 
SMART
  
PROSITE
 PS00154; ATPASE_E1_E2
 PS01047; HMA_1
 PS50846; HMA_2 
PRINTS
 PR00119; CATATPASE.