CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013061
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box only protein 7 
Protein Synonyms/Alias
  
Gene Name
 Fbxo7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
297EPGESAAKVYKDLKKubiquitination[1]
394RGPDTDWKELYRKKHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5 (By similarity). 
Sequence Annotation
 DOMAIN 330 376 F-box.  
Keyword
 Complete proteome; Cytoplasm; Nucleus; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 523 AA 
Protein Sequence
MKLRVRLQKR TQPLEVPESE PTLGQLRAHL SQVLLPTLGF SSDTRFAITL NNKDALTGDE 60
ETLASYGIVS GDLICLVLED DMPAPNLPSS TDTEHSSLQD NDQPSLAATP SQTNIPDEQG 120
TDSSQGQATP FDAWTDDSME GPSQNVEAES IQDAMSMEEV SGFHPLEPML CNETEDGQVP 180
HSLETLYQSA GCSNISDALI VLVHLLMLES GYIPQGTETK AVTMPEKWKS SGVYKLQYTH 240
PLCEGGFAVL TCVPLGNLII INATIKVNGG IKNVKSVQLQ PGSYVAAGVE PGESAAKVYK 300
DLKKLSRLFK DQLVYPLLAF TRQVLNLPDV FGLVVLPLEL KLRIFRLLDV HSVLALSAVC 360
HDLLIASNDP LLWRCLYLRD FRDGTVRGPD TDWKELYRKK HIQRKEAQRM RHAMFLPSAH 420
PIPFCPIPVY PRAYLPTSLL PPGIIGGEYD ERPILPSVGD PVTSLIPRPG ELPGQFRPLR 480
PRFDPVDPLP GPHSLLPGRA IPNNRFPFRP GRGRSADSRL PFL 523 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
 GO:0031647; P:regulation of protein stability; IEA:Compara. 
Interpro
 IPR001810; F-box_dom_cyclin-like.
 IPR021625; Inhibitor_PI31. 
Pfam
 PF11566; PI31_Prot_N 
SMART
  
PROSITE
 PS50181; FBOX 
PRINTS