CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006745
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 L-2-hydroxyglutarate oxidase LhgO 
Protein Synonyms/Alias
  
Gene Name
 lhgO 
Gene Synonyms/Alias
 ygaF; b2660; JW2635 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
156DVTAAMAKIFQSRGGacetylation[1]
178VSGLNEHKNGVVIRTacetylation[1]
355QAVSPDGKLIDDFLFacetylation[1]
392IGAHIVSKVQTLLASacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate. 
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 422 AA 
Protein Sequence
MYDFVIIGGG IIGMSTAMQL IDVYPDARIA LLEKESAPAC HQTGHNSGVI HAGVYYTPGS 60
LKAQFCLAGN RATKAFCDQN GIRYDNCGKM LVATSDLEME RMRALWERTA ANGIEREWLN 120
ADELREREPN ITGLGGIFVP SSGIVSYRDV TAAMAKIFQS RGGEIIYNAE VSGLNEHKNG 180
VVIRTRQGGE YEASTLISCS GLMADRLVKM LGLEPGFIIC PFRGEYFRLA PEHNQIVNHL 240
IYPIPDPAMP FLGVHLTRMI DGSVTVGPNA VLAFKREGYR KRDFSFSDTL EILGSSGIRR 300
VLQNHLRSGL GEMKNSLCKS GYLRLVQKYC PRLSLSDLQP WPAGVRAQAV SPDGKLIDDF 360
LFVTTPRTIH TCNAPSPAAT SAIPIGAHIV SKVQTLLASQ SNPGRTLRAA RSVDALHAAF 420
NQ 422 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:EcoliWiki.
 GO:0050660; F:flavin adenine dinucleotide binding; IDA:EcoCyc.
 GO:0034419; F:L-2-hydroxyglutarate oxidase activity; IDA:EcoCyc.
 GO:0052853; F:long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity; IEA:EC.
 GO:0052854; F:medium-chain-(S)-2-hydroxy-acid oxidase activity; IEA:EC.
 GO:0052852; F:very-long-chain-(S)-2-hydroxy-acid oxidase activity; IEA:EC. 
Interpro
 IPR006076; FAD-dep_OxRdtase. 
Pfam
 PF01266; DAO 
SMART
  
PROSITE
  
PRINTS