UniProt Accession

 B4DYB8_HUMAN; B4DYB8 

Genbank Protein ID

 AC125435; AK302354 

Genbank Nucleotide ID

 BAG63680.1 

Protein Name

 Mannose-6-phosphate isomerase 

Protein Synonyms/Alias

 cDNA FLJ54812, moderately similar to Mannose-6-phosphate isomerase (EC 5.3.1.8) 

Gene Name

 MPI 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	THPRGDAKILDNRIS	ubiquitination	[1]
19	LDNRISQKTLSQWIA	ubiquitination	[1, 2]
35	NQDSLGSKVKDTFNG	ubiquitination	[1]
37	DSLGSKVKDTFNGNL	ubiquitination	[1]
65	SIQAHPNKELAEKLH	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Isomerase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 228 AA 

Protein Sequence

Gene Ontology

 GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
 GO:0009298; P:GDP-mannose biosynthetic process; IEA:InterPro. 

Interpro

 IPR001250; Man6P_Isoase-1.
 IPR016305; Mannose-6-P_Isomerase.
 IPR018050; Pmannose_isomerase-type1_CS.
 IPR014710; RmlC-like_jellyroll.
 IPR011051; RmlC_Cupin. 

Pfam

 PF01238; PMI_typeI 

SMART

  

PROSITE

 PS00965; PMI_I_1 

PRINTS

 PR00714; MAN6PISMRASE.