UniProt Accession

 ZKSC3_HUMAN; Q9BRR0; B2R8W2; B3KVC0; H7BXX1; Q5VXH3; Q92972; Q9H4T3 

Genbank Protein ID

 BT007427; AK122790; AK313532; AL358785; AL021997; AL021997; AL358785; CH471081; BC006118; U71601 

Genbank Nucleotide ID

 AAP36095.1; BAG53732.1; BAG36309.1; CAH71668.1; CAH71668.1; CAI23088.1; CAI23088.1; EAX03157.1; AAH06118.1; AAB16813.1 

Protein Name

 Zinc finger protein with KRAB and SCAN domains 3 

Protein Synonyms/Alias

 Zinc finger and SCAN domain-containing protein 13; Zinc finger protein 306; Zinc finger protein 309; Zinc finger protein 47 homolog; Zf47; Zfp-47 

Gene Name

 ZKSCAN3 

Gene Synonyms/Alias

 ZFP47; ZNF306; ZNF309; ZSCAN13 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
82	LQPEMHSKEQILELL	methylation	[1]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

 Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas. 

Sequence Annotation

 DOMAIN 46 128 SCAN box.
 DOMAIN 214 274 KRAB.
 ZN_FING 314 336 C2H2-type 1.
 ZN_FING 342 364 C2H2-type 2.
 ZN_FING 370 392 C2H2-type 3.
 ZN_FING 398 420 C2H2-type 4.
 ZN_FING 426 448 C2H2-type 5.
 ZN_FING 480 502 C2H2-type 6.
 ZN_FING 508 530 C2H2-type 7.  

Keyword

 Alternative splicing; Autophagy; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 538 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IPI:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:0007040; P:lysosome organization; IMP:UniProtKB.
 GO:0010507; P:negative regulation of autophagy; IMP:UniProtKB.
 GO:2000773; P:negative regulation of cellular senescence; IMP:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0016032; P:viral reproduction; IEA:InterPro. 

Interpro

 IPR001909; Krueppel-associated_box.
 IPR008916; Retrov_capsid_C.
 IPR003309; Tscrpt_reg_SCAN.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF01352; KRAB
 PF02023; SCAN 

SMART

 SM00349; KRAB
 SM00431; SCAN
 SM00355; ZnF_C2H2 

PROSITE

 PS50805; KRAB
 PS50804; SCAN_BOX
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS