CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023714
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calsenilin 
Protein Synonyms/Alias
 A-type potassium channel modulatory protein 3; DRE-antagonist modulator; DREAM; Kv channel-interacting protein 3; KChIP3 
Gene Name
 KCNIP3 
Gene Synonyms/Alias
 CSEN; DREAM; KCHIP3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26LGHTPLSKKEGIKWQsumoylation[1]
90QAQTKFTKKELQSLYsumoylation[1]
241EFLEACQKDENIMSSsumoylation[1]
Reference
 [1] Sumoylation regulates nuclear localization of repressor DREAM.
 Palczewska M, Casafont I, Ghimire K, Rojas AM, Valencia A, Lafarga M, Mellström B, Naranjo JR.
 Biochim Biophys Acta. 2011 May;1813(5):1050-8. [PMID: 21070824] 
Functional Description
 Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). 
Sequence Annotation
 DOMAIN 67 123 EF-hand 1; degenerate.
 DOMAIN 126 161 EF-hand 2.
 DOMAIN 162 197 EF-hand 3.
 DOMAIN 210 245 EF-hand 4.
 REGION 243 256 Interaction with KCND2 (By similarity).
 MOD_RES 63 63 Phosphoserine; by CK1.
 LIPID 45 45 S-palmitoyl cysteine (By similarity).
 LIPID 46 46 S-palmitoyl cysteine (By similarity).
 CROSSLNK 26 26 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 90 90 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Alternative splicing; Apoptosis; Calcium; Cell membrane; Complete proteome; Cytoplasm; Endoplasmic reticulum; Golgi apparatus; Ion channel; Ion transport; Isopeptide bond; Lipoprotein; Membrane; Metal-binding; Nucleus; Palmitate; Phosphoprotein; Polymorphism; Potassium; Potassium channel; Potassium transport; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Transport; Ubl conjugation; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 256 AA 
Protein Sequence
MQPAKEVTKA SDGSLLGDLG HTPLSKKEGI KWQRPRLSRQ ALMRCCLVKW ILSSTAPQGS 60
DSSDSELELS TVRHQPEGLD QLQAQTKFTK KELQSLYRGF KNECPTGLVD EDTFKLIYAQ 120
FFPQGDATTY AHFLFNAFDA DGNGAIHFED FVVGLSILLR GTVHEKLKWA FNLYDINKDG 180
YITKEEMLAI MKSIYDMMGR HTYPILREDA PAEHVERFFE KMDRNQDGVV TIEEFLEACQ 240
KDENIMSSMQ LFENVI 256 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; TAS:ProtInc.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW.
 GO:0015459; F:potassium channel regulator activity; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0007610; P:behavior; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0043523; P:regulation of neuron apoptotic process; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0048265; P:response to pain; IEA:Compara.
 GO:0019233; P:sensory perception of pain; IEA:Compara.
 GO:0007165; P:signal transduction; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR001125; Recoverin. 
Pfam
 PF13499; EF_hand_5 
SMART
 SM00054; EFh 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS
 PR00450; RECOVERIN.