CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003933
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vitamin D3 receptor 
Protein Synonyms/Alias
 VDR; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1 
Gene Name
 VDR 
Gene Synonyms/Alias
 NR1I1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
302YRVSDVTKAGHSLELubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. 
Sequence Annotation
 DNA_BIND 21 96 Nuclear receptor.
 ZN_FING 24 44 NR C4-type.
 ZN_FING 60 84 NR C4-type.
 REGION 97 191 Hinge.
 REGION 192 427 Ligand-binding.
 REGION 227 237 Vitamin D3 binding.
 REGION 271 278 Vitamin D3 binding.
 BINDING 143 143 Vitamin D3.
 BINDING 305 305 Vitamin D3.
 BINDING 397 397 Vitamin D3.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Disease mutation; DNA-binding; Metal-binding; Nucleus; Polymorphism; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 427 AA 
Protein Sequence
MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR SMKRKALFTC 60
PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV QRKREMILKR KEEEALKDSL 120
RPKLSEEQQR IIAILLDAHH KTYDPTYSDF CQFRPPVRVN DGGGSHPSRP NSRHTPSFSG 180
DSSSSCSDHC ITSSDMMDSS SFSNLDLSEE DSDDPSVTLE LSQLSMLPHL ADLVSYSIQK 240
VIGFAKMIPG FRDLTSEDQI VLLKSSAIEV IMLRSNESFT MDDMSWTCGN QDYKYRVSDV 300
TKAGHSLELI EPLIKFQVGL KKLNLHEEEH VLLMAICIVS PDRPGVQDAA LIEAIQDRLS 360
NTLQTYIRCR HPPPGSHLLY AKMIQKLADL RSLNEEHSKQ YRCLSFQPEC SMKLTPLVLE 420
VFGNEIS 427 
Gene Ontology
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:1902098; F:calcitriol binding; IDA:UniProtKB.
 GO:0008434; F:calcitriol receptor activity; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:1902121; F:lithocholic acid binding; IDA:UniProtKB.
 GO:0038186; F:lithocholic acid receptor activity; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0000902; P:cell morphogenesis; IMP:UniProtKB.
 GO:0046697; P:decidualization; IEP:BHF-UCL.
 GO:0010839; P:negative regulation of keratinocyte proliferation; IMP:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0045618; P:positive regulation of keratinocyte differentiation; IMP:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
 GO:0010980; P:positive regulation of vitamin D 24-hydroxylase activity; IDA:BHF-UCL.
 GO:0060558; P:regulation of calcidiol 1-monooxygenase activity; ISS:BHF-UCL.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome. 
Interpro
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR000324; VitD_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.
 PR00350; VITAMINDR.