UniProt Accession

 ACYP1_HUMAN; P07311; A6NDV8; B2R590 

Genbank Protein ID

 X84194; AK312101; AC007055; AL049780; CH471061; BC035568; BG614847 

Genbank Nucleotide ID

 CAA58987.1; BAG35037.1; AAD31937.1; EAW81216.1; AAH35568.1 

Protein Name

 Acylphosphatase-1 

Protein Synonyms/Alias

 Acylphosphatase, erythrocyte isozyme; Acylphosphatase, organ-common type isozyme; Acylphosphate phosphohydrolase 1 

Gene Name

 ACYP1 

Gene Synonyms/Alias

 ACYPE 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	HTQAEGKKLGLVGWV	ubiquitination	[1, 2]
58	QLQGPISKVRHMQEW	ubiquitination	[1, 2, 3]
89	NNEKVILKLDYSDFQ	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Its physiological role is not yet clear. 

Sequence Annotation

 DOMAIN 9 99 Acylphosphatase-like.
 ACT_SITE 24 24 Potential.
 ACT_SITE 42 42 Potential.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Hydrolase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 99 AA 

Protein Sequence

Gene Ontology

 GO:0003998; F:acylphosphatase activity; TAS:ProtInc.
 GO:0006796; P:phosphate-containing compound metabolic process; TAS:ProtInc. 

Interpro

 IPR020456; Acylphosphatase.
 IPR001792; Acylphosphatase-like.
 IPR017968; Acylphosphatase_CS. 

Pfam

 PF00708; Acylphosphatase 

SMART

  

PROSITE

 PS00150; ACYLPHOSPHATASE_1
 PS00151; ACYLPHOSPHATASE_2
 PS51160; ACYLPHOSPHATASE_3 

PRINTS

 PR00112; ACYLPHPHTASE.