CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010119
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Trigger factor 
Protein Synonyms/Alias
 TF; PPIase 
Gene Name
 tig 
Gene Synonyms/Alias
 MPN_331; MP505 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
12KLVNTTQKEKTLCLEacetylation[1]
28AIDTKLWKETQQKQTacetylation[1]
43QDLTKNMKIKGFRKGacetylation[1]
45LTKNMKIKGFRKGKVacetylation[1]
141LSPIVPLKDEEFNKEacetylation[1]
147LKDEEFNKELHNIEKacetylation[1]
154KELHNIEKNKGKLVDacetylation[1]
225DKRQLKLKFPKDYHAacetylation[1]
277YQGFNSLKEFKTYFHacetylation[1]
280FNSLKEFKTYFHKLVacetylation[1]
285EFKTYFHKLVSAKKLacetylation[1]
333DRLLRAQKDQAEQYKacetylation[1]
340KDQAEQYKIPFERLLacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). 
Sequence Annotation
 DOMAIN 170 255 PPIase FKBP-type.  
Keyword
 Cell cycle; Cell division; Chaperone; Complete proteome; Cytoplasm; Isomerase; Reference proteome; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 444 AA 
Protein Sequence
MKQYKLVNTT QKEKTLCLEI AIDTKLWKET QQKQTQDLTK NMKIKGFRKG KVPPTLAKDY 60
LDRAELLQRS AQAVIDAIFQ PLQQEAVIAD NENVIEDFPT IDFKTINEND CVILFDFDLV 120
PQFEPPDYKH IKDLSPIVPL KDEEFNKELH NIEKNKGKLV DVSDKALANN DIAVIDFVGK 180
VDGKVLESAT AKQYELTIGS NSFIDGFESG LIGMKVGDKR QLKLKFPKDY HAEELKGKPV 240
EFDIELKAIK QLEITPMDET NFKEYLPAQY QGFNSLKEFK TYFHKLVSAK KLEITLQENS 300
VKIRQFFLAN TTLPYIPDSL IKLESDRLLR AQKDQAEQYK IPFERLLAAS KLSLEQLQQR 360
NIKEARDNVT FALVMKRIAD VEKIKVDNKK IHSEIESIID VEYPFVNAEL KKQMFHNMEQ 420
QKDFVESIIL NRLTTTKIIE YSTH 444 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:HAMAP.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:HAMAP.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC.
 GO:0015031; P:protein transport; IEA:HAMAP. 
Interpro
 IPR001179; PPIase_FKBP_dom.
 IPR005215; Trig_fac.
 IPR008880; Trigger_fac_C.
 IPR008881; Trigger_fac_ribosome-bd_bac.
 IPR027304; Trigger_fact/SurA_dom. 
Pfam
 PF00254; FKBP_C
 PF05698; Trigger_C
 PF05697; Trigger_N 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE 
PRINTS