| Tag | Content |
|---|
| CPLM ID | CPLM-011917 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium voltage-gated channel subfamily H member 2 |
Protein Synonyms/Alias | Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Voltage-gated potassium channel subunit Kv11.1 |
Gene Name | KCNH2 |
Gene Synonyms/Alias | ERG; ERG1; HERG |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 287 | TLNFVDLKGDPFLAS | ubiquitination | [1] | | 332 | ADVLPEYKLQAPRIH | ubiquitination | [1] | | 840 | SFRRRTDKDTEQPGE | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1. |
Sequence Annotation | DOMAIN 41 70 PAS.
DOMAIN 92 144 PAC.
NP_BIND 742 842 cNMP.
MOTIF 624 629 Selectivity filter (By similarity).
MOD_RES 320 320 Phosphoserine.
CARBOHYD 598 598 N-linked (GlcNAc...). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Deafness; Disease mutation; Glycoprotein; Ion channel; Ion transport; Long QT syndrome; Membrane; Phosphoprotein; Polymorphism; Potassium; Potassium channel; Potassium transport; Reference proteome; Short QT syndrome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1159 AA |
Protein Sequence | MPVRRGHVAP QNTFLDTIIR KFEGQSRKFI IANARVENCA VIYCNDGFCE LCGYSRAEVM 60
QRPCTCDFLH GPRTQRRAAA QIAQALLGAE ERKVEIAFYR KDGSCFLCLV DVVPVKNEDG 120
AVIMFILNFE VVMEKDMVVD VDLTPAAPSS ESLALDEVTA MDNHVAGLGP AEERRALVGP 180
GSPPRSAPGQ LPSPRAHSLN PDASGSSCSL ARTRSRESCA SVRRASSADD IEAMRAGVLP 240
PPPRHASTGA MHPLRSGLLN STSDSDLVRY RTISKIPQIT LNFVDLKGDP FLASPTSDRE 300
IIAPKIKERT HNVTEKVTQV LSLGADVLPE YKLQAPRIHR WTILHYSPFK AVWDWLILLL 360
VIYTAVFTPY SAAFLLKETE EGPPATECGY ACQPLAVVDL IVDIMFIVDI LINFRTTYVN 420
ANEEVVSHPG RIAVHYFKGW FLIDMVAAIP FDLLIFGSGS EELIGLLKTA RLLRLVRVAR 480
KLDRYSEYGA AVLFLLMCTF ALIAHWLACI WYAIGNMEQP HMDSRIGWLH NLGDQIGKPY 540
NSSGLGGPSI KDKYVTALYF TFSSLTSVGF GNVSPNTNSE KIFSICVMLI GSLMYASIFG 600
NVSAIIQRLY SGTARYHTQM LRVREFIRFH QIPNPLRQRL EEYFQHAWSY TNGIDMNAVL 660
KGFPECLQAD ICLHLNRSLL QHCKPFRGAT KGCLRALAMK FKTTHAPPGD TLVHAGDLLT 720
ALYFISRGSI EILRGDVVVA ILGKNDIFGE PLNLYARPGK SNGDVRALTY CDLHKIHRDD 780
LLEVLDMYPE FSDHFWSSLE ITFNLRDTNM IPGSPGSTEL EGGFSRQRKR KLSFRRRTDK 840
DTEQPGEVSA LGPGRAGAGP SSRGRPGGPW GESPSSGPSS PESSEDEGPG RSSSPLRLVP 900
FSSPRPPGEP PGGEPLMEDC EKSSDTCNPL SGAFSGVSNI FSFWGDSRGR QYQELPRCPA 960
PTPSLLNIPL SSPGRRPRGD VESRLDALQR QLNRLETRLS ADMATVLQLL QRQMTLVPPA 1020
YSAVTTPGPG PTSTSPLLPV SPLPTLTLDS LSQVSQFMAC EELPPGAPEL PQEGPTRRLS 1080
LPGQLGALTS QPLHRHGSDP GS 1102 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:Compara. GO:0005635; C:nuclear envelope; IEA:Compara. GO:0008076; C:voltage-gated potassium channel complex; TAS:ProtInc. GO:0005251; F:delayed rectifier potassium channel activity; TAS:ProtInc. GO:0005242; F:inward rectifier potassium channel activity; IEA:Compara. GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro. GO:0008015; P:blood circulation; NAS:ProtInc. GO:0006936; P:muscle contraction; TAS:ProtInc. GO:0086091; P:regulation of heart rate by cardiac conduction; IMP:MGI. GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Compara. GO:0023014; P:signal transduction by phosphorylation; IEA:GOC. GO:0007268; P:synaptic transmission; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |