| Tag | Content |
|---|
| CPLM ID | CPLM-013357 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leucine-rich repeat flightless-interacting protein 2 |
Protein Synonyms/Alias | LRR FLII-interacting protein 2 |
Gene Name | Lrrfip2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 159 | SLSEVEEKYKKAMVS | acetylation | [1] | | 227 | QHKMDELKEGLRQRD | acetylation | [1] | | 293 | LRKLAEEKDELLSQI | acetylation | [1] | | 392 | EKIEDELKAEKRKLQ | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity). |
Sequence Annotation | MOD_RES 18 18 Phosphoserine (By similarity).
MOD_RES 125 125 Phosphoserine (By similarity).
MOD_RES 129 129 Phosphoserine (By similarity).
MOD_RES 133 133 Phosphoserine (By similarity).
MOD_RES 136 136 Phosphothreonine (By similarity).
MOD_RES 138 138 Phosphoserine (By similarity). |
Keyword | Coiled coil; Complete proteome; Phosphoprotein; Reference proteome; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 437 AA |
Protein Sequence | MGTPGSGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM RELERQQRES 60
SSKDITGTHW SRASTPKRRD MMYDSIKDRS SRVSSLLDEK SDKQYAENYT RPSSRNSASA 120
TTPLSGNSSR RGSGDTSSLI DPDTSLSELR ESLSEVEEKY KKAMVSNAQL DNEKNNLIYQ 180
VDTLKDVIEE QEEQMAEFYR ENEEKSKELE RQKHMCSVLQ HKMDELKEGL RQRDELIEKH 240
GLVIIPESTP NGDVNHEPVV GAITAVSQEA AQVLESAGEG PLDVRLRKLA EEKDELLSQI 300
RKLKLQLEEE RQKCSRNDGM SGDLAGLQNG SDLQFIEMQR DANRQISEYK FKLSKAEQDI 360
ATLEQSISRL EGQVLRYKTA AENAEKIEDE LKAEKRKLQR ELRTAQDKIE EMEMTNSHLA 420
KRLEKMKANR TALLAQQ 437 |
Gene Ontology | GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |