CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014548
UniProt Accession
Genbank Protein ID
 D49446 
Genbank Nucleotide ID
Protein Name
 Transcription initiation factor TFIID subunit 6 
Protein Synonyms/Alias
 Transcription initiation factor TFIID 70 kDa subunit; TAF(II)70; TAFII70; Transcription initiation factor TFIID 80 kDa subunit; TAF(II)80; TAFII-80; TAFII80; p80 
Gene Name
 Taf6 
Gene Synonyms/Alias
 Taf2e 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
191GAAAADGKGKEKKAPubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (By similarity). 
Sequence Annotation
 MOD_RES 248 248 Phosphothreonine.
 MOD_RES 253 253 Phosphotyrosine.
 MOD_RES 264 264 Phosphoserine.
 MOD_RES 653 653 Phosphoserine (By similarity).
 MOD_RES 660 660 Phosphothreonine (By similarity).  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 678 AA 
Protein Sequence
MAEEKKLKLS NTVLPSESMK VVAESMGIAQ IQEETCQLLT DEVSYRIKEI AQDALKFMHM 60
GKRQKLTTSD IDYALKLKNV EPLYGFHAQE FIPFRFASGG GRELYFYEEK EVDLSDIINT 120
PLPRVPLDVC LKAHWLSIEG CQPAIPENPP PAPKEQQKAE ATEPLKSAKP GQEEDGPLKG 180
KGQGAAAADG KGKEKKAPPL LEGAPFRLKP RSIHELSVEQ QLYYKEITEA CVGSCEAKRA 240
EALQSIATDP GLYQMLPRFS TFISEGVRVN VVQNNLALLI YLMRMVKALM DNPTLYLEKY 300
VHELIPAVMT CIVSRQLCLR PDVDNHWALR DFAARLVAQI CKHFSTTTNN IQSRITKTFT 360
KSWVDEKTPW TTRYGSIAGL AELGHDVIKT LILPRLQQEG ERIRSVLDGP VLSNIDRIGA 420
DHVQSLLLKH CAPVLAKLRP PPDNQDAYRG EFGSLGPLLC SHVVKARAQA ALQAQQVNRT 480
TLTITQPRPT LTLSQAPQPG PRTPGLLKVP GSIALPVQTL VSARAAAPPQ PSPPPTKFIV 540
MSSSSSASST QQVLSLSTSA PGSGSTTTSP VTTTVPSVQP IVKLVSTATT APPSTAPAGP 600
GSVQKYIVVS LPPTGEGKGG PPSHPSPVPP SSSSPSPLGG SALCGGKQET GDSPPPAPGT 660
PKANGSQPTG PSSPQPAL 678 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0071339; C:MLL1 complex; ISS:UniProtKB.
 GO:0005669; C:transcription factor TFIID complex; IEA:Compara.
 GO:0033276; C:transcription factor TFTC complex; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0045786; P:negative regulation of cell cycle; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR011989; ARM-like.
 IPR011442; DUF1546.
 IPR009072; Histone-fold.
 IPR004823; TAF_TATA-bd. 
Pfam
 PF07571; DUF1546
 PF02969; TAF 
SMART
 SM00803; TAF 
PROSITE
  
PRINTS