UniProt Accession

 SSRA_HUMAN; P43307; A8K685; Q53GX2; Q53H19; Q5TAM3; Q6IB43; Q8NBH9; Q96IA2; Q9TNQ8; Q9UN49 

Genbank Protein ID

 Z12830; AF156965; BT007387; AK291550; CR456961; AK222762; AK222809; AK075562; AL139095; BC007710 

Genbank Nucleotide ID

 CAA78290.1; AAD48778.1; AAP36051.1; BAF84239.1; CAG33242.1; BAD96482.1; BAD96529.1; BAC11701.1; CAI16444.1; AAH07710.1 

Protein Name

 Translocon-associated protein subunit alpha 

Protein Synonyms/Alias

 TRAP-alpha; Signal sequence receptor subunit alpha; SSR-alpha 

Gene Name

 SSR1 

Gene Synonyms/Alias

 TRAPA; PSEC0262 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
102	FPANNIVKFLVGFTN	ubiquitination	[1, 2]
110	FLVGFTNKGTEDFIV	ubiquitination	[2]
266	ETLNQINKASPRRLP	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. 

Sequence Annotation

 MOD_RES 247 247 Phosphoserine.
 MOD_RES 260 260 Phosphothreonine.
 MOD_RES 268 268 Phosphoserine.
 CARBOHYD 136 136 N-linked (GlcNAc...).
 CARBOHYD 191 191 N-linked (GlcNAc...).  

Keyword

 Alternative splicing; Calcium; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 286 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006412; P:translation; TAS:Reactome. 

Interpro

 IPR005595; TRAP_alpha. 

Pfam

 PF03896; TRAP_alpha 

SMART

  

PROSITE

  

PRINTS