UniProt Accession

 RLMA_ECOLI; P36999 

Genbank Protein ID

 D28496; U00096; AP009048 

Genbank Nucleotide ID

 BAA05855.1; AAC74892.1; BAA15633.1 

Protein Name

 23S rRNA (guanine(745)-N(1))-methyltransferase 

Protein Synonyms/Alias

 23S rRNA m1G745 methyltransferase; Ribosomal RNA large subunit methyltransferase A 

Gene Name

 rlmA 

Gene Synonyms/Alias

 rrmA; yebH; b1822; JW1811 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
31	RHQFDMAKEGYVNLL	acetylation	[1]
43	NLLPVQHKRSRDPGD	acetylation	[1]
160	IRIYAPCKAEELARV	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Specifically methylates the guanosine in position 745 of 23S rRNA. 

Sequence Annotation

 REGION 96 97 S-adenosyl-L-methionine binding.
 METAL 5 5 Zinc.
 METAL 8 8 Zinc.
 METAL 21 21 Zinc.
 METAL 25 25 Zinc.
 BINDING 67 67 S-adenosyl-L-methionine.
 BINDING 183 183 S-adenosyl-L-methionine.  

Keyword

 3D-structure; Complete proteome; Metal-binding; Methyltransferase; Reference proteome; rRNA processing; S-adenosyl-L-methionine; Transferase; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 269 AA 

Protein Sequence

Gene Ontology

 GO:0052911; F:23S rRNA (guanine(745)-N(1))-methyltransferase activity; IEA:EC.
 GO:0008989; F:rRNA (guanine-N1-)-methyltransferase activity; IDA:EcoCyc.
 GO:0008270; F:zinc ion binding; IDA:EcoCyc.
 GO:0070475; P:rRNA base methylation; IMP:EcoCyc. 

Interpro

 IPR025714; Methyltranfer_dom.
 IPR016718; rRNA_m1G-MeTrfase_A_prd. 

Pfam

 PF13847; Methyltransf_31 

SMART

  

PROSITE

  

PRINTS