CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014573
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycine receptor subunit alpha-1 
Protein Synonyms/Alias
 Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit 
Gene Name
 Glra1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
414KSPEEMRKLFIQRAKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). 
Sequence Annotation
 REGION 225 230 Strychnine-binding (By similarity).
 CARBOHYD 66 66 N-linked (GlcNAc...) (Probable).
 DISULFID 166 180 By similarity.
 DISULFID 226 237 By similarity.  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 457 AA 
Protein Sequence
MYSFNTLRFY LWETIVFFSL AASKEAEAAR SAPKPMSPSD FLDKLMGRTS GYDARIRPNF 60
KGPPVNVSCN IFINSFGSIA ETTMDYRVNI FLRQQWNDPR LAYNEYPDDS LDLDPSMLDS 120
IWKPDLFFAN EKGAHFHEIT TDNKLLRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC 180
IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEE KDLRYCTKHY NTGKFTCIEA 240
RFHLERQMGY YLIQMYIPSL LIVILSWISF WINMDAAPAR VGLGITTVLT MTTQSSGSRA 300
SLPKVSYVKA IDIWMAVCLL FVFSALLEYA AVNFVSRQHK ELLRFRRKRR HHKSPMLNLF 360
QDDEGGEGRF NFSAYGMGPA CLQAKDGISV KGANNNNTTN PPPAPSKSPE EMRKLFIQRA 420
KKIDKISRIG FPMAFLIFNM FYWIIYKIVR REDVHNK 457 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
 GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
 GO:0045211; C:postsynaptic membrane; IDA:MGI.
 GO:0016934; F:extracellular-glycine-gated chloride channel activity; ISS:UniProtKB.
 GO:0016594; F:glycine binding; ISS:UniProtKB.
 GO:0030977; F:taurine binding; ISS:UniProtKB.
 GO:0022824; F:transmitter-gated ion channel activity; IEA:InterPro.
 GO:0007340; P:acrosome reaction; IMP:MGI.
 GO:0007628; P:adult walking behavior; IMP:MGI.
 GO:0006936; P:muscle contraction; ISS:UniProtKB.
 GO:0051970; P:negative regulation of transmission of nerve impulse; ISS:UniProtKB.
 GO:0050884; P:neuromuscular process controlling posture; IMP:MGI.
 GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
 GO:2000344; P:positive regulation of acrosome reaction; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0001508; P:regulation of action potential; IMP:MGI.
 GO:0060080; P:regulation of inhibitory postsynaptic membrane potential; IMP:MGI.
 GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; IMP:MGI.
 GO:0060013; P:righting reflex; IMP:MGI.
 GO:0001964; P:startle response; ISS:UniProtKB.
 GO:0060012; P:synaptic transmission, glycinergic; IMP:MGI.
 GO:0007601; P:visual perception; IMP:MGI. 
Interpro
 IPR006028; GABAA_rcpt.
 IPR008127; Glycine_rcpt_A.
 IPR008128; Glycine_rcpt_A1.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS. 
Pfam
 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 
SMART
  
PROSITE
 PS00236; NEUROTR_ION_CHANNEL 
PRINTS
 PR00253; GABAARECEPTR.
 PR01673; GLYRALPHA.
 PR01674; GLYRALPHA1.
 PR00252; NRIONCHANNEL.