UniProt Accession

 3BHS5_RAT; P27364; Q569C6 

Genbank Protein ID

 M67465; BC092571 

Genbank Nucleotide ID

 AAA41352.1; AAH92571.1 

Protein Name

 3 beta-hydroxysteroid dehydrogenase type 5 

Protein Synonyms/Alias

 3 beta-hydroxysteroid dehydrogenase type V; 3-beta-HSD V; 3-beta-hydroxy-5-ene steroid dehydrogenase; NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; Progesterone reductase 

Gene Name

 Hsd3b5 

Gene Synonyms/Alias

 Hsd3b 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
27	VQMLVQEKELQEVRV	acetylation	[1]
44	RTFSPKHKEELSKLQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD V can only catalyze the conversion of dihydrotestosterone to 5 alpha- androstanediol in the presence of the cofactor NADPH. Exhibits only 3-ketosteroid reductase activity in the presence of NADPH and does not function as an isomerase. 

Sequence Annotation

 ACT_SITE 155 155 Proton acceptor (By similarity).
 BINDING 159 159 NAD (By similarity).
 MOD_RES 42 42 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Endoplasmic reticulum; Membrane; Mitochondrion; NADP; Oxidoreductase; Reference proteome; Steroidogenesis; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 373 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IDA:RGD.
 GO:0051287; F:NAD binding; IDA:RGD.
 GO:0005496; F:steroid binding; IDA:RGD.
 GO:0042448; P:progesterone metabolic process; IDA:RGD.
 GO:0050810; P:regulation of steroid biosynthetic process; IDA:RGD.
 GO:0006694; P:steroid biosynthetic process; IDA:RGD. 

Interpro

 IPR002225; 3Beta_OHSteriod_DH/Estase.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF01073; 3Beta_HSD 

SMART

  

PROSITE

  

PRINTS