CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019151
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein DGCR14 
Protein Synonyms/Alias
 DiGeorge syndrome critical region 13; DiGeorge syndrome critical region 14; DiGeorge syndrome protein H; DGS-H; Protein ES2 
Gene Name
 DGCR14 
Gene Synonyms/Alias
 DGCR13; DGSH; DGSI; ES2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
66VEKLQAQKEYLEAEEubiquitination[1]
93KFGSALGKMSREPPPubiquitination[1]
171QEIMEVAKERSRARHubiquitination[1]
221ETWKYKAKNSLMYYPubiquitination[1]
276AALNAQHKQGKVGPDubiquitination[1, 2]
279NAQHKQGKVGPDGKEubiquitination[1]
285GKVGPDGKELIPQESubiquitination[1, 2]
345RTPGPAFKILEPGRRubiquitination[1, 3, 4]
358RRERLGLKMANEAAAubiquitination[1]
408LVSRTASKYTDRALRacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May be involved in pre-mRNA splicing. 
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 391 391 Phosphoserine.
 MOD_RES 395 395 Phosphoserine.  
Keyword
 Acetylation; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Spliceosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 476 AA 
Protein Sequence
METPGASASS LLLPAASRPP RKREAGEAGA ATSKQRVLDE EEYIEGLQTV IQRDFFPDVE 60
KLQAQKEYLE AEENGDLERM RQIAIKFGSA LGKMSREPPP PYVTPATFET PEVHAGTGVV 120
GNKPRPRGRG LEDGEAGEEE EKEPLPSLDV FLSRYTSEDN ASFQEIMEVA KERSRARHAW 180
LYQAEEEFEK RQKDNLELPS AEHQAIESSQ ASVETWKYKA KNSLMYYPEG VPDEEQLFKK 240
PRQVVHKNTR FLRDPFSQAL SRCQLQQAAA LNAQHKQGKV GPDGKELIPQ ESPRVGGFGF 300
VATPSPAPGV NESPMMTWGE VENTPLRVEG SETPYVDRTP GPAFKILEPG RRERLGLKMA 360
NEAAAKNRAK KQEALRRVTE NLASLTPKGL SPAMSPALQR LVSRTASKYT DRALRASYTP 420
SPARSTHLKT PASGLQTPTS TPAPGSATRT PLTQDPASIT DNLLQLPARR KASDFF 476 
Gene Ontology
 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB.
 GO:0007399; P:nervous system development; ISS:UniProtKB. 
Interpro
 IPR019148; Nuclear_protein_DGCR14. 
Pfam
 PF09751; Es2 
SMART
  
PROSITE
  
PRINTS