UniProt Accession

 HTAI2_HUMAN; Q9BUP3; A8K7S7; D3DQY8; O15383; O60520; O95345; Q53GC1; Q53GG2; Q6IBI3 

Genbank Protein ID

 U69161; AF039103; AF092095; AK292092; CR456821; AK223010; AK222969; AC025972; CH471064; CH471064; BC002439; BC015358 

Genbank Nucleotide ID

 AAB84360.1; AAC39694.1; AAC78331.1; BAF84781.1; CAG33102.1; BAD96730.1; BAD96689.1; EAW68338.1; EAW68339.1; AAH02439.2; AAH15358.1 

Protein Name

 Oxidoreductase HTATIP2 

Protein Synonyms/Alias

 30 kDa HIV-1 TAT-interacting protein; HIV-1 TAT-interactive protein 2 

Gene Name

 HTATIP2 

Gene Synonyms/Alias

 CC3; TIP30 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
70	ETGRVLLKEILEQGL	ubiquitination	[1, 2]
97	TFDEEAYKNVNQEVV	ubiquitination	[2]
132	CLGTTRGKAGAEGFV	ubiquitination	[2]
148	VDRDYVLKSAELAKA	ubiquitination	[2]
171	LSSKGADKSSNFLYL	ubiquitination	[1, 2, 3]
262	QMELLENKAIHDLGK	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. 

Sequence Annotation

 NP_BIND 19 52 NADP.
 ACT_SITE 143 143 Proton acceptor (Probable).
 ACT_SITE 147 147 Probable.
 BINDING 131 131 Substrate (Probable).
 MOD_RES 45 45 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Angiogenesis; Apoptosis; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Host-virus interaction; NADP; Nucleus; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 242 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005635; C:nuclear envelope; IDA:UniProtKB.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB.
 GO:0051170; P:nuclear import; IDA:UniProtKB.
 GO:0045765; P:regulation of angiogenesis; IDA:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR016040; NAD(P)-bd_dom. 

Pfam

  

SMART

  

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PRINTS