CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015103
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA/RNP complex-1-interacting phosphatase 
Protein Synonyms/Alias
 Dual specificity protein phosphatase 11; Phosphatase that interacts with RNA/RNP complex 1 
Gene Name
 Dusp11 
Gene Synonyms/Alias
 Pir1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
266SSPYSLRKWSQNQSVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 It has both, RNA 5'-diphosphatase and 5'-triphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolism (By similarity). 
Sequence Annotation
 DOMAIN 127 196 Tyrosine-protein phosphatase.
 ACT_SITE 151 151 Phosphocysteine intermediate (By  
Keyword
 Complete proteome; Hydrolase; Nucleus; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 321 AA 
Protein Sequence
MNQHYGRHGR GRGRDFAACA PPKKKGRNHI PERWKDYLPV GQRMPGTRFI AFKVPLQKKF 60
EAKLMPEECF SPLDLFNKIQ EQNEELGLII DLTYTQRYYK VEDLPETISY IKIFTVGHQI 120
PDNDTIFQFK CAVKEFLKKN KNNDKLIGVH CTHGLNRTGY LICRYLIDVE GMRPDDAIEL 180
FNSCRGHCIE RQNYIENLQK RHVRKNRNVS APRTDGLEDS ADPTEQVYTN NKPVKKKPRK 240
NRRGGHLAPS QHFQHQTQSS PYSLRKWSQN QSVYQRGLVP PPGPAGEDYS QRRFFWSARP 300
NKWTAESYQR PFYPYYWEWN L 321 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS. 
Pfam
 PF00782; DSPc 
SMART
  
PROSITE
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50054; TYR_PHOSPHATASE_DUAL 
PRINTS