UniProt Accession

 UB2E2_HUMAN; Q96LR5 

Genbank Protein ID

 AK057886; BC022332 

Genbank Nucleotide ID

 BAB71605.1; AAH22332.1 

Protein Name

 Ubiquitin-conjugating enzyme E2 E2 

Protein Synonyms/Alias

 UbcH8; Ubiquitin carrier protein E2; Ubiquitin-protein ligase E2 

Gene Name

 UBE2E2 

Gene Synonyms/Alias

 UBCH8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	KEGKISSKTAAKLST	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. 

Sequence Annotation

 ACT_SITE 139 139 Glycyl thioester intermediate (By
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 19 19 Phosphoserine.  

Keyword

 3D-structure; Acetylation; ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042296; F:ISG15 ligase activity; IDA:HGNC.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
 GO:0032020; P:ISG15-protein conjugation; IDA:HGNC.
 GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.
 GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.
 GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB. 

Interpro

 IPR000608; UBQ-conjugat_E2.
 IPR023313; UBQ-conjugating_AS.
 IPR016135; UBQ-conjugating_enzyme/RWD. 

Pfam

 PF00179; UQ_con 

SMART

  

PROSITE

 PS00183; UBIQUITIN_CONJUGAT_1
 PS50127; UBIQUITIN_CONJUGAT_2 

PRINTS