CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018248
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 PYROXD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
54IKAVTNFKQISKILEubiquitination[1, 2]
75QSSTMLGKRFPNIKVubiquitination[2]
88KVIESGVKQLKSEEHubiquitination[2]
108DGNQHVYKKLCLCAGubiquitination[2]
109GNQHVYKKLCLCAGAubiquitination[2]
117LCLCAGAKPKLICEGubiquitination[2]
142DSAQEFQKQLTKAKRubiquitination[2, 3, 4, 5]
178VIWAIKDKAIGNTFFubiquitination[2]
196AAEFLTSKLIAEKSEubiquitination[2]
201TSKLIAEKSEAKIAHubiquitination[2]
246WHEGLNLKGTKEFSHubiquitination[2]
265ETMCEVKKIYLQDEFubiquitination[2]
278EFRILKKKSFTFPRDubiquitination[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine.  
Keyword
 Acetylation; Complete proteome; FAD; Flavoprotein; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 500 AA 
Protein Sequence
MEAARPPPTA GKFVVVGGGI AGVTCAEQLA THFPSEDILL VTASPVIKAV TNFKQISKIL 60
EEFDVEEQSS TMLGKRFPNI KVIESGVKQL KSEEHCIVTE DGNQHVYKKL CLCAGAKPKL 120
ICEGNPYVLG IRDTDSAQEF QKQLTKAKRI MIIGNGGIAL ELVYEIEGCE VIWAIKDKAI 180
GNTFFDAGAA EFLTSKLIAE KSEAKIAHKR TRYTTEGRKK EARSKSKADN VGSALGPDWH 240
EGLNLKGTKE FSHKIHLETM CEVKKIYLQD EFRILKKKSF TFPRDHKSVT ADTEMWPVYV 300
ELTNEKIYGC DFIVSATGVT PNVEPFLHGN SFDLGEDGGL KVDDHMHTSL PDIYAAGDIC 360
TTSWQLSPVW QQMRLWTQAR QMGWYAAKCM AAASSGDSID MDFSFELFAH VTKFFNYKVV 420
LLGKYNAQGL GSDHELMLRC TKGREYIKVV MQNGRMMGAV LIGETDLEET FENLILNQMN 480
LSSYGEDLLD PNIDIEDYFD 500 
Gene Ontology
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. 
Interpro
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD. 
Pfam
 PF07992; Pyr_redox_2 
SMART
  
PROSITE
  
PRINTS
 PR00368; FADPNR.