| Tag | Content |
|---|
| CPLM ID | CPLM-024733 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | FCH domain only protein 2 |
Protein Synonyms/Alias | |
Gene Name | Fcho2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 183 | TYKLYVEKYALTKAD | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor (By similarity). |
Sequence Annotation | DOMAIN 4 85 FCH.
DOMAIN 541 808 MHD.
REGION 3 274 Mediates dimerization and binding to
REGION 520 809 Mediates interaction with DAB2, EPS15,
MOD_RES 385 385 Phosphothreonine (By similarity).
MOD_RES 387 387 Phosphoserine (By similarity).
MOD_RES 394 394 Phosphoserine (By similarity).
MOD_RES 402 402 Phosphoserine (By similarity).
MOD_RES 403 403 Phosphoserine (By similarity).
MOD_RES 487 487 Phosphoserine (By similarity).
MOD_RES 508 508 Phosphoserine (By similarity).
MOD_RES 510 510 Phosphoserine (By similarity).
MOD_RES 532 532 Phosphoserine (By similarity).
DISULFID 147 147 Interchain (with C-273) (By similarity).
DISULFID 273 273 Interchain (with C-147) (By similarity). |
Keyword | Coated pit; Coiled coil; Complete proteome; Disulfide bond; Endocytosis; Membrane; Phosphoprotein; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 809 AA |
Protein Sequence | MVMAHFVENF WGEKNNGFDV LYHNMKHGQI STKELADFVR ERATIEEAYS RSMTKLAKSA 60
SNYSQLGTFA PVWDVFKTST EKLANCHLDL VRKLQELIKE VQKYGEEQVK SHKKTKEEVA 120
GTLEAVQAIQ NITQALQKSK ENYNAKCVEQ ERLKKEGATP REIEKAAVKS KKATDTYKLY 180
VEKYALTKAD FEQKMTETAQ KFQDIEETHL IHIKEIIGSL SNAIKEIHLQ IGQVHEEFIN 240
NMANTTIESL IQKFAESKGT GKERPGLIEF EECDPASAVE GIKPRKRKTF ALPGIIKKEK 300
DAESVECPDA DSLNIPDVDE EGFSIKPEAN QNDTKENHFY SSSDSDSEDE EPKRYRIEIK 360
PVHPNNVHHT MASLDELKVS IGNITLSPAV SRHSPVQMNR NSSNEELTKS KPSSLPTEKG 420
TNDLLAWDPL FGSSLESSSA PLTSSSSARP TTPLSLGTIV PPPRPASRPK LTSGKLSGIN 480
EIPRPFSPPI TSNTSPPPTA PLARAESSSS ISSSASLSAA NTPTVGVSRG PSPVSLGNQD 540
TLPVAIALTE SVNAYFKGAD PTKCIVKITG DVTISFPSGI IKVFTSNPSP AVLCFRVKNI 600
SRLEQILPNS QLVFSDPSQC DSNTKDFWMN MQAVTVYLKK LSEQNPAASY YNVDVLKYQV 660
SSNGIQSTPL NLATYWKCSA STTDLRVDYK YNPEAMVAPS VLSNIQVVVP VDGGVTNMQS 720
LPPAIWNAEQ MKAFWKLSGI SEKSDSGGSG SLRAKFDLSE GPSKPATLAV QFLSEGNTLS 780
GVDIELVGTG YRLSLVKKRF ATGRYLADC 809 |
Gene Ontology | GO:0030136; C:clathrin-coated vesicle; IEA:Compara. GO:0005905; C:coated pit; ISS:UniProtKB. GO:0005886; C:plasma membrane; ISS:UniProtKB. GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:UniProtKB. GO:0001786; F:phosphatidylserine binding; ISS:UniProtKB. GO:0048268; P:clathrin coat assembly; ISS:UniProtKB. GO:0072583; P:clathrin-mediated endocytosis; ISS:UniProtKB. GO:0010324; P:membrane invagination; ISS:UniProtKB. GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |