CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019690
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Na(+)/H(+) antiporter 
Protein Synonyms/Alias
  
Gene Name
 NHA1 
Gene Synonyms/Alias
 YLR138W; L3149; L9606.4 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
475QRLPSLDKAGRSFSLubiquitination[1]
505AEEGGGRKGLAGGEDubiquitination[1]
569EIFSSRSKNEMYDDDubiquitination[1]
698KMKEEEMKPGTAYLDubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 Sodium export from cell, takes up external protons in exchange for internal sodium ions (By similarity). 
Sequence Annotation
 MOD_RES 568 568 Phosphoserine.
 MOD_RES 765 765 Phosphothreonine.
 MOD_RES 768 768 Phosphoserine.
 MOD_RES 774 774 Phosphoserine.  
Keyword
 Antiport; Complete proteome; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 985 AA 
Protein Sequence
MAIWEQLEVS KAHVAYACVG VFSSIFSLVS LYVKEKLYIG ESTVAGIFGL IVGPVCLNWF 60
NPLKWGNSDS ITLEITRIVL CLQIFAVAVE LPRKYMLKHW VSVTMLLLPV MTAGWLIIGL 120
FVWILIPGLN FSASLLISAC ITATDPILAQ SVVSGKFAQR VPGHLRNLLS AESGCNDGMA 180
FPFLFLSMNL ILHPGNGREI VKDWICVTIL YECLFGCLLG CFIGYVGRIT IRFAEKKNII 240
DRESFLAFYV VLAFMCAGFG SILGVDDLLV SFAAGATFAW DGWFSQKTQE SNVSTVIDLL 300
LNYAYFIYFG AIIPWSQFNN GEIGTNVWRL IILSIVVIFL RRIPAVMILR PLIPDIKSWR 360
EALFVGHFGP IGVGAIFAAI LARGELESTF SDEPTPLNVV PSKEESKHWQ LIACIWPITC 420
FFIVTSIIVH GSSVAIITLG RHLNTITLTK TFTTHTTNGD NGKSSWMQRL PSLDKAGRSF 480
SLHRMDTQMT LSGDEGEAEE GGGRKGLAGG EDEEGLNNDQ IGSVATSGIP ARPAGGMPRR 540
RKLSRKEKRL NRRQKLRNKG REIFSSRSKN EMYDDDELND LGRERLQKEK EARAATFALS 600
TAVNTQRNEE IGMGGDEEED EYTPEKEYSD NYNNTPSFES SERSSSLRGR TYVPRNRYDG 660
EETESEIESE DEMENESERS MASSEERRIR KMKEEEMKPG TAYLDGNRMI IENKQGEILN 720
QVDIEDRNEA RDDEVSVDST AHSSLTTTMT NLSSSSGGRL KRILTPTSLG KIHSLVDKGK 780
DKNKNSKYHA FKIDNLLIIE NEDGDVIKRY KINPHKSDDD KSKNRPRNDS VVSRALTAVG 840
LKSKANSGVP PPVDEEKAIE GPSRKGPGML KKRTLTPAPP RGVQDSLDLE DEPSSEEDLG 900
DSYNMDDSED YDDNAYESET EFERQRRLNA LGEMTAPADQ DDEELPPLPV EAQTGNDGPG 960
TAEGKKKQKS AAVKSALSKT LGLNK 985 
Gene Ontology
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0045121; C:membrane raft; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0015385; F:sodium:hydrogen antiporter activity; IDA:SGD.
 GO:0030007; P:cellular potassium ion homeostasis; IMP:SGD.
 GO:0006970; P:response to osmotic stress; IMP:SGD. 
Interpro
 IPR013928; Cation/H_antiporter_C.
 IPR006153; Cation/H_exchanger.
 IPR004712; NaH_exchanger_fun. 
Pfam
 PF00999; Na_H_Exchanger
 PF08619; Nha1_C 
SMART
  
PROSITE
  
PRINTS