UniProt Accession

 CAPG_HUMAN; P40121; B8ZZS7; D6W5K8; Q53SA7 

Genbank Protein ID

 M94345; AK225374; AC062037; CH471053; CH471053; CH471053; CH471053; BC000728; BC014549; U12026 

Genbank Nucleotide ID

 AAA59570.1; AAY24128.1; EAW99517.1; EAW99518.1; EAW99519.1; EAW99520.1; AAH00728.1; AAH14549.1; AAA92670.1 

Protein Name

 Macrophage-capping protein 

Protein Synonyms/Alias

 Actin regulatory protein CAP-G 

Gene Name

 CAPG 

Gene Synonyms/Alias

 AFCP; MCP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
115	SYFPRGLKYQEGGVE	ubiquitination	[1]
127	GVESAFHKTSTGAPA	ubiquitination	[1]
243	EEDLTADKANAQAAA	ubiquitination	[2]
297	CGKIYIWKGRKANEK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. 

Sequence Annotation

 REPEAT 27 75 Gelsolin-like 1.
 REPEAT 148 188 Gelsolin-like 2.
 REPEAT 261 307 Gelsolin-like 3.
 MOTIF 137 146 Nuclear localization signal (Potential).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 337 337 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Actin capping; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 348 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0008290; C:F-actin capping protein complex; TAS:ProtInc.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0051016; P:barbed-end actin filament capping; TAS:ProtInc.
 GO:0030031; P:cell projection assembly; IEA:Compara.
 GO:0006461; P:protein complex assembly; NAS:ProtInc. 

Interpro

 IPR007123; Gelsolin_dom.
 IPR007122; Villin/Gelsolin. 

Pfam

 PF00626; Gelsolin 

SMART

 SM00262; GEL 

PROSITE

  

PRINTS

 PR00597; GELSOLIN.